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By Target- ADC Linker
- Estrogen Receptor/ERR(1)
- PROTACs(1)
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Results for "
hetero-bifunctional
" in TargetMol Product Catalog- Inhibitors & Agonists2
- PROTAC Products2
ARV-471
Vepdegestrant
T397102229711-68-4In house
Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.
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Sulfo-SMCC sodium
T1872892921-24-9
Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively.
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