hcc1806

Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.

C-176 (STING inhibitor 1) is a STING inhibitor with selectivity and blood-brain barrier permeability. C-176 inhibits STING-mediated IFNβ production and possesses anti-inflammatory activity.

VEGFR-2-IN-60 (compound 5c) is a potent VEGFR-2 inhibitor with an IC50 of 1.07 nM and exhibits cytotoxic activity against HCC1806, Hela, and A549 cell lines.

SZ-015268 is a CDK7 inhibitor (IC50: 23.56 nM) that inhibits the proliferation of HCC70 (IC50: 33 nM), OVCAR-3 (IC50: 80.56 nM), HCT116 (IC50: 12.53 nM), and HCC1806 (IC50: 61.55 nM) cells, exhibiting a highly significant anti-tumor effect.

eEF2K degrader-1 is a degrader of eEF2K, known to inhibit the viability, proliferation, and migration of MDA-MB-231 and HCC1806 cell lines, with an IC50 value of 43.71 nM in MDA-MB-231 cells. Furthermore, eEF2K degrader-1 demonstrates tumor-suppressive effects in a xenograft mouse model using MDA-MB-231 cells.

LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester) is a novel CDK7 inhibitors.