ha15

HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.

HA15-Biotin is a chemically synthesized compound comprising HA15 which is connected to biotin through the amide group. It demonstrates comparable activity to HA15 and holds potential for use in proteomic analysis.

Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.

Sirtratumab (also known as AGS15C / Ha15-10ac12) is a human monoclonal antibody targeting SLITRK6. It is used in cancer research, particularly in tumor models with high SLITRK6 expression, to investigate the role of SLITRK6 in tumor growth, proliferation, migration, and other biological processes. As a candidate antibody for ADC development, an antibody–drug conjugate derived from Sirtratumab (Sirtratumab vedotin / AGS15E) has been developed to selectively deliver cytotoxic agents to SLITRK6-positive tumor cells, thereby enhancing targeting specificity.