h-ras intron 1 cpg island

Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms.

Eicosapentaenoic Acid (EPA) sodium, an orally active omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA), demonstrates a unique ability to demethylate DNA, thereby facilitating the re-expression of the tumor suppressor gene CCAAT enhancer-binding protein δ (C EBPδ). This compound also activates the RAS ERK C EBPβ pathway by demethylating H-Ras intron 1 CpG island in U937 leukemia cells and promotes the relaxation of vascular smooth muscle cells, leading to vasodilation.