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gdc0068

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  • Inhibitors & Agonists
    2
    TargetMol | Inhibitors_Agonists
Ipatasertib
RG7440, GDC-0068
T62521001264-89-6
Ipatasertib (GDC-0068) is a selective, ATP-competitive pan-Akt inhibitor that inhibits Akt1 (IC50:5 nM), Akt2 (IC50:18 nM), and Akt3 (IC50:8 nM). Ipatasertib (GDC-0068) can lead to p53-independent PUMA activation by inhibiting Akt, thereby activating FoxO3a and NF-κB simultaneously, directly binding to the PUMA promoter, upregulating PUMA transcription and Bax-mediated intrinsic mitochondrial apoptosis.
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TargetMol | Inhibitor Hot
BMS-986034
T705501492631-88-5
BMS-986034 is a GPR119 agonist.
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10-14 weeks
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