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Results for "
gdc 0927
" in TargetMol Product Catalog- Inhibitors & Agonists3
GDC-0927
SRN-927
T113801642297-01-5
GDC-0927 is a novel,non-steroidal, potent, orally bioavailable, selective estrogen receptor antagonist.
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GDC-0927 Racemate
SRN-927 Racemate
T137001443983-36-5
GDC-0927 Racemate is a degrader of estrogen receptor, is used in the research of ER-related diseases, potently inhibits ER-α activity, with an IC50 of 0.2 nM.
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GNE-274
T399162369048-69-9
GNE-274, a non-degrader compound structurally similar to GDC-0927 (an ER degrader), serves as a partial ER agonist in breast cancer cell lines without triggering ER turnover. Notably, GNE-274 enhances chromatin accessibility at ER-DNA binding sites, unlike GDC-0927. Acting as a potent inhibitor of the ER-ligand binding domain (LBD), GNE-274 exhibits potential for cancer research purposes.
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