gallstone

glycohyodeoxycholic acid is a major metabolite of the secondary bile acid hyodeoxycholic acid in humans.

CIMBA hydrochloride is a selective antagonist of the G protein-coupled estrogen receptor (GPER). It can be utilized in research related to cholesterol gallstone disease in women.

β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4]

SSTR5 antagonist 3 (Compound 23) serves as a potent somatostatin receptor subtype 5 (SSTR5) antagonist, demonstrating oral activity and minimal hERG inhibition. It shows significant efficacy, with IC50 values of 2.8 nM in humans and 1.4 nM in mice. This compound is utilized in gallstone research [1].

β-Muricholic Acid (Standard) is a reference standard for research and analysis in studies involving β-Muricholic Acid. β-Muricholic acid (β-MCA) is a primary bile acid unique to rodents. Administering β-MCA through diet can reduce the activity of HMG-CoA reductase in the liver microsomes of mice fed with high cholesterol and chenodeoxycholic acid diets. Giving β-MCA can also cause 100% of the cholesterol-containing gallstones in the diet-induced gallstone model to dissolve.

12-Ketochenodeoxycholic acid (Standard) is a reference standard for research and analysis in studies involving 12-Ketochenodeoxycholic acid. 12-Ketochenodeoxycholic acid 12 is a direct precursor of cholodeoxycholic acid (CDCA). 12-Ketochenodeoxycholic acid 12 supports bile acid biosynthesis studies since CDCA is used to dissolve cholesterol gallstones and exhibits chemotherapeutic properties, enabling scientific investigation into bile acid metabolism, gallstone dissolution pathways, and hepatobiliary disease intervention mechanisms with enhanced experimental applicability and translational value.

12-Ketochenodeoxycholic acid 12 is a direct precursor of cholodeoxycholic acid (CDCA). 12-Ketochenodeoxycholic acid 12 supports bile acid biosynthesis studies since CDCA is used to dissolve cholesterol gallstones and exhibits chemotherapeutic properties, enabling scientific investigation into bile acid metabolism, gallstone dissolution pathways, and hepatobiliary disease intervention mechanisms with enhanced experimental applicability and translational value.