g0s2

NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).

LRH-1 Inhibitor-3 is an antagonist that inhibits LRH-1 transcriptional activity, reducing the expression of target genes associated with cell growth and proliferation, such as SHP (small heterodimer partner), cyclin E1 (CCNE1), and G0S2, and inhibiting the proliferation of human pancreatic, colon, and breast adenocarcinoma cells.

LRH-1 antagonist-1 (Compound 3d2) is an LRH-1 antagonist with a Kd of 1.8 μM. It inhibits LRH-1 transcriptional activity and reduces G0S2 expression. Additionally, LRH-1 antagonist-1 suppresses the proliferation of LRH-1 positive cancer cells and can be utilized for research in pancreatic, colon, and breast cancers.

LRH-1 antagonist-1 (Compound 3d2) dihydrochloride is an LRH-1 antagonist with a Kd of 1.8 μM. It inhibits LRH-1 transcriptional activity and reduces G0S2 expression. Additionally, LRH-1 antagonist-1 dihydrochloride suppresses the proliferation of LRH-1 positive cancer cells and can be utilized in the study of pancreatic, colon, and breast cancers.