fx11

FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer.

DFX117 is an orally effective selective inhibitor of PI3Kα and c-Met tyrosine kinase (c-Met). This compound inhibits the PI3K Akt mTOR pathway and suppresses the proliferation of NCI-H1975, NCI-H1993, and HCC827 cells, with IC50 values ranging from 0.02 to 0.08 µM. Additionally, DFX117 induces cell cycle arrest in the G0 G1 phase and triggers apoptosis (apoptosis) in A549 and NCI-H1975 cells. It also exhibits antitumor activity in mice.