foxp3 expression

BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).

P60-L3-VHL, a PROTAC class Foxp3 degrader, exhibits antitumor activity by reducing cell differentiation and Foxp3 expression in activated Treg cells in vitro.

(S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor of C57BL/6 mouse allografted with mouse LLC cells at 200 mg/kg, induction of IDO1 protein expression in tumor of C57BL/6 mouse allografted with mouse LLC cells at 200 mg/kg, antitumor activity against mouse LLC cells allografted in C57BL/6 mouse, antiproliferative activity against mouse LLC cells at 50 uM.

Cobitolimod, a DNA oligonucleotide agonist of TLR-9 with anti-inflammatory properties, suppresses Th17 cells and promotes the expression of anti-inflammatory FoxP3 and IL-10, thereby inhibiting the IL-17 signaling pathway [1].

Cobitolimod sodium, a DNA oligonucleotide agonist of TLR-9 with anti-inflammatory activity, inhibits Th17 cells and induces anti-inflammatory FoxP3 and IL-10 expression, thereby inhibiting the IL-17 signaling pathway [1].

CDK8-IN-15 (Compound 46) is a potent inhibitor of CDK8, exhibiting an IC50 value of 57 nM. This compound enhances the thermal stability of CDK8 and inhibits NF-κB, while selectively targeting the CDK family and tyrosine kinases. Additionally, it actively counteracts TNF-α-induced psoriasis in vitro and boosts the expression of Foxp3 and IL-10, potentially diminishing inflammatory responses and showing promise for research into psoriasis treatments.

Fulvotomentoside A could decrease overexpression of IL-6 and IL-17A, and increase the expression of specific transcription factor Foxp3 of regulatory T cells significantly in intestine. It may be one of the mechanisms that Ful improved intestinal inflamma

CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling.

CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.