fluphenazine hydrochloride

Fluphenazine hydrochloride is an effective, orally active phenothiazine class dopamine receptor (dopamine receptor) antagonist. It blocks voltage-gated sodium ion channels (sodium channels) in neurons. The compound primarily exerts its effects by antagonizing postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular pathways. It counteracts stereotypy induced by methylphenidate in mice and suppresses climbing behavior. Fluphenazine hydrochloride is used in studying psychoses and diabetic-related painful peripheral neuropathy, with potential to inhibit SARS-CoV-2.

Fluphenazine dihydrochloride (Prolixin) is an inhibitor of phenothiazine-class D1DR and D2DR; In studies, Fluphenazine can be used to probe the effects and metabolic process of this commonly used dopamine antagonist.

Fluphenazine-N-2-chloroethane hydrochloride is a fluphenazine derivative containing a chloroethyl alkyl group that forms covalent bonds with calmodulin; it is commonly used as a chemical probe for studying calmodulin function and related signaling pathways.

Fluphenazine-D8 Dihydrochloride is a deuterated compound of Fluphenazine Dihydrochloride. Fluphenazine Dihydrochloride (T0068) has a CAS number of 146-56-5. Fluphenazine dihydrochloride is an inhibitor of phenothiazine-class D1DR and D2DR; In studies, Fluphenazine can be used to probe the effects and metabolic process of this commonly used dopamine antagonist.