fluorescence

Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogenous compound acetylcholine. Administered as an ophthalmic solution, this drug stimulates the cholinoceptors in the sphincter muscle of the iris, causing the pupil to constrict.

IA-Alkyne (Iodoacetamide-alkyne) is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling. It also has the potential for the study of respiratory infection.

UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells.

Compound E1, also known as G-quadruplex DNA fluorescence probe 1, is a selective fluorescent probe targeting G-quadruplex DNA. It possesses the ability to penetrate membranes and enter living cells, demonstrating low cytotoxicity [1].

IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.IMP-1710 has antifibrotic activity. [1]

7-Amino-4-methylcoumarin-3-acetic acid [7-Amino-4-methylcoumarin] is a more suitable substrate for enteropeptidase compared to GD(4)K-NA.

GLF16 HCl (GLF16) belongs to fluorescent dyes and is a fluorescent Sudan Black B analog, serving as a non-targeted probe. This compound possesses good cell permeability and is suitable for live cells and in vivo environments. The probe enables rapid detection, isolation, and real-time tracking of senescent cells via fluorescence microscopy and flow cytometry.

Mutant IDH1-IN-2 is an inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with an IC50 of 16.6 nM in fluorescence biochemical assay and an IC50 of <22 nM in LS-MS biochemical assay.

O-Propargyl-Puromycin ( OP-puro) is a natural product derivative and a protein synthesis inhibitor with cell permeability. It terminates translational elongation by incorporation into nascent peptide chains, and is widely used for nascent protein labeling and detection, enabling fluorescence imaging or affinity enrichment when combined with click chemistry.

Rufigallol (AI3-00865) is an electron-deficient disk-shaped molecule with six hydroxyl groups and is a good unit for inducing the formation of DLC from non-planar AIE molecules, an anthraquinone derivative.Rufigallol induces the acquisition of DLC properties, while the introduction of TPE groups gives the molecular structure good fluorescence in the aggregated state.The remarkable synergistic in vitro antimalarial effect, in vivo with vitamin C and ketones was synergistic and showed antimalarial activity.

IR820-PTX is a nanoparticle composed of IR-820 and paclitaxel that is highly permeable and tumor-targeting.IR820-PTX can be used for near-infrared fluorescence imaging and tumor diagnostics.9-cis-Retinoic Acetylcholine (RAC) is a nanoparticle that is highly permeable and tumor-targeting.

Chlorobenzothiazolinone inhibits recombinant human chymase using bis(succinoyl-L-alanyl-L-prolyl-L-phenylalanylamide) as substrate after 1 hr by fluorescence assay with activity value of 90 μM.

Acridine is a classic fluorescent pH indicator that combines stability and fluorescence properties. Its tricyclic conjugated molecular structure can achieve pH response. In different pH environments, Acridine molecules undergo protonation or deprotonation transformations, and this structural change significantly alters their fluorescence properties.

Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally, fluorescing tetracycline binds to a newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry.

Anthracene is a polycyclic aromatic hydrocarbon (PAH) consisting of three fused benzene rings that presents as a colorless, solid, crystalline substance derived primarily from coal tar, known for its characteristic blue fluorescence under ultraviolet light and its extensive use as a fundamental raw material for producing anthraquinone dyes, synthetic fibers, and various other organic compounds. While Anthracene serves as a component in some wood preservatives and asphalt products, Anthracene is also a recognized environmental pollutant and is classified as a potential occupational carcinogen by some regulatory bodies.

Br-Mmc (4-Bromomethyl-7-methoxycoumarin) is a novel fluorescence label utilized in the determination of fatty acids via HPLC or TLC.

Ac-LETD-AFC is a fluorescent substrate specifically cleaved by caspase-8 and can be used to quantify caspase activity by fluorescence detection of free AFC.Ac-LETD-AFC has an excitation wavelength of 400 nm and an emission wavelength of 505 nm.

1,3,5-tris(pyridin-4-ylethynyl)benzene is a heterocyclic compound with a wide range of properties such as fluorescence and electrochemical activity with relatively low toxicity. It has been used as a building block for the synthesis of various materials such as polymers, nanomaterials and organic light emitting diodes (OLEDs). It is also a promising material for the development of novel drug delivery systems.

D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluorescence analysis of D-amino acid oxidase.

GSK 4027 is a PCAF/GCN5 bromodomain chemical probe. In a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, it has a pIC50 of 7.4±0.11 for PCAF.

KMG-301AM, the acetoxy methyl esterified form of KMG-301, facilitates the acquisition of time-course and pseudo-colored images depicting the changes in mitochondrial fluorescence when stained with KMG-301.

resorufin galactopyranoside is a fluorescent substrate for β-galactosidase.After cleavage by β-galactosidase, the fluorescent portion of resorufin is released and its fluorescence can be used to quantify β-galactosidase activity. It has an excitation light of 570 and an emission light of 580 nm.

5-TAMRA can produce bright, pH insensitive orange fluorescence (Ex/ Em= 546 / 579nm), and has good photostability

D-Ala-Lys-AMCA hydrochloride, a known substrate of proton-coupled oligopeptide transporter 1 (PEPT1), emits blue fluorescence and may be transported into Caco-2 cells and liver cancer cells.