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(2)
By Target- FGFR
- Apoptosis(1)
- SNIPERs(1)
- Others(1)
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Results for "
fgfr3-tacc3
" in TargetMol Product Catalog- Inhibitors & Agonists3
- PROTAC Products1
LC-MF-4
T211928
LC-MF-4 is a selective FGFR3 PROTAC degrader with a DC50 of 30.89 nM in KMS-11 cells. It inhibits the metabolic functions of FGFR3-TACC3 fusion-positive cancers by reducing ATP synthesis and suppressing mitochondrial biogenesis genes. LC-MF-4 demonstrates potent anti-tumor activity in the Ba/F3-FGFR3-TACC3 xenograft mouse model and is applicable for research on FGFR3 gene mutation cancers such as bladder cancer and urothelial carcinoma (UC).
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SNIPER(TACC3)-11
T744622906151-68-4
SNIPER(TACC3)-11 is a potent degrader of the FGFR3-TACC3 protein, significantly reducing its levels and inhibiting the proliferation of FGFR3-TACC3-positive cancer cells [1].
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