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Results for "

fas-induced

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  • Inhibitors & Agonists
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    TargetMol | Recombinant_Protein
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p53 Protein, Mouse, Recombinant (His & SUMO)
Tumor suppressor p53, Trp53, Tp53, P53, Cellular tumor antigen p53
TMPH-02574
Expression system: E. coli
Length: 1-387, Partial
Activity: Not Tested
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20 days
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TargetMol | Inhibitor Hot
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Serpin B9 Protein, Human, Recombinant (His)
serpin peptidase inhibitor, clade B (ovalbumin), member 9, Serpin B9, PI-9, PI9, CAP-3, CAP3
TMPY-02210
SerpinB9, also known as Cytoplasmic antiproteinase 3, CAP-3, Peptidase inhibitor 9, SERPINB9 and PI-9, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. Serpin-B9 ( CAP-3 PI-9 ) is the only known human intracellular inhibitor of granzyme B (GrB), the effector molecule in immunity against cytomegalovirus (CMV) and in renal allograft rejection. Serpin-B9 and SPI-6 expression in immune-privileged cells, APCs, and CTLs protect these cells against the actions of granzyme B, and when expressed in tumor cells or virally infected hepatocytes, confers resistance to killing by CTL and NK cells. Expression of increasing levels of Serpin-B9 ( CAP-3 PI-9 ) in target cells may progressively inhibit immune surveillance by blocking NK and CTL-induced cytotoxicity through the perforin granzyme pathway and then through the Fas FasL pathway. Serpin-B9 ( CAP-3 PI-9 ) is selectively up-regulated in hepatocytes in response to infiltration of the liver by NK cells that express perforin and enzymatically active granzyme B. Upregulated expression of Serpin-B9 ( CAP-3 PI-9 ) in NSCLC cells may serve to protect them from apoptosis induced by GrB.
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7-10 days
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IL-12B Protein, Cynomolgus, Recombinant (His)
NKSF2, NKS, IL-12B, IL-12 subunit p40, CLMF2, CLMF p40, CLMF
TMPK-01378
Interleukin (IL)‑12B, which encodes the p40 subunit common to IL‑12 and IL‑23, as one of the genes for which expression in fibroblast‑like synoviocytes from patients with rheumatoid arthritis (RA‑FLS) is induced by DcR3.Decoy receptor 3 (DcR3) competitively binds to three ligands, Fas ligand, lymphotoxin‑related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells and tumor necrosis factor‑like ligand 1A (TL1A), to prevent their effects. Recent studies have suggested that DcR3 directly affects cells as a ligand.
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7-10 days
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SPR-compatible buffer
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p53 Protein, Rat, Recombinant (His)
Tumor suppressor p53, Tp53, P53, Cellular tumor antigen p53
TMPH-03264
Expression system: E. coli
Length: 1-391, Full Length
Activity: Not Tested
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20 days
Size
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