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Results for "
etanercept
" in TargetMol Product Catalog- Inhibitors & Agonists1
- Inhibitory Antibodies1
- Recombinant Protein1
Etanercept
T37445185243-69-0
Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.[1]
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CompareTNFRSF1B, TNFR80, TNF-R75, TNF-R2, TNFR2, TNFR1B, TNFBR, TNF RII, TBPII, p75TNFR, p75TBPII, Etanercept, CD120b
TMPK-01382
Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
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