estradiol (standard)

Estradiol (Standard) is the standard substance of Estradiol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor beta (ERβ).

Alpha-Estradiol (Standard) is the standard substance of Alpha-Estradiol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.

Ethynyl estradiol (Standard) is the standard substance of Ethynyl estradiol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.

4-Methoxy 17β-Estradiol (Standard) is a reference standard for research and analysis in studies involving 4-Methoxy 17β-Estradiol. 4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol.

2-Methoxyestradiol (Standard) is a reference standard for research and analysis in studies involving 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis.

17Alpha-Ethynyl-13C2-Estradiol (Standard) is a reference standard of 17Alpha-Ethynyl-13C2-Estradiol intended for quantitative analysis, quality control, and related biochemical research applications.

4-Methoxy-[13C,D3]-Estradiol (Standard) is a reference standard of 4-Methoxy-[13C,D3]-Estradiol intended for quantitative analysis, quality control, and related biochemical research applications.

2-Methoxy-[13C,D3]-Estradiol (Standard) is a reference standard of 2-Methoxy-[13C,D3]-Estradiol intended for quantitative analysis, quality control, and related biochemical research applications.

3-O-methyl Estradiol is a synthetic estrogen known for its ability to interfere with microtubule networks in V79 Chinese hamster cells, with an EC50 value of 9 µM. At a concentration of 20 µM, it inhibits the proliferation of these cells by 92%. Additionally, when male rats on a high-cholesterol diet are administered 3-O-methyl Estradiol (25 mg in a 0.2 ml solution, p.o.), it results in decreased serum cholesterol levels and increases body weight loss, suggesting feminizing effects. It has also been utilized as a standard for quantifying 17β-estradiol in hen urine.

17β-Estradiol-2,4-D2 (Standard) is a reference material suitable for analytical purposes, including quantitative analysis, quality control, and biochemical experiments.

Estriol (Standard) is the standard substance of Estriol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Estriol (Oestriol) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.

Estrone (Standard) is the standard substance of Estrone, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

2-Methoxyestrone (Standard) is a reference standard for research and analysis in studies involving 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and the principal metabolite of 2-hydroxyestrone, a nonuterotropic metabolite of estradiol.

16α-Hydroxyestrone (Standard) is a reference standard for research and analysis in studies involving 16α-Hydroxyestrone. The naturally-occurring estrogens are estrone , estradiol , and estriol . 16α-hydroxy Estrone (16α-OHE1) is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. 16α-OHE1 is sulphatized or glucuronidated before excretion. It is increased in rheumatoid arthritis and decreased by physical activity. Unlike the parent estrogens and other hydroxylated metabolites of E1, 16α-OHE1 binds covalently and persistently activates estrogen receptors. In addition, this metabolite increases cell proliferation and does not suppress TNF-α secretion, whereas other estrogen metabolites are not pro-proliferative and have marked effects on TNF-α secretion. The levels of 16α-OHE1 are increased in some forms of hormone therapy. Because hormone therapy increases breast cancer risk, 16α-OHE1 has been implicated as a risk factor for breast cancer, although supportive data remains elusive.

17β-Estradiol-13C3 Undecanoate (Standard) is a reference standard of 17β-Estradiol-13C3 Undecanoate intended for quantitative analysis, quality control, and related biochemical research applications.

17β-Estradiol-[2,3,4-13C3] (Standard) is a reference standard of 17β-Estradiol-[2,3,4-13C3] intended for quantitative analysis, quality control, and related biochemical research applications.

16α-Hydroxy-17β-Estradiol-2,4-D2 (Standard) is a reference standard of 16α-Hydroxy-17β-Estradiol-2,4-D2 intended for quantitative analysis, quality control, and related biochemical research applications. 16α-Hydroxy-17β-estradiol-2,4-d2 is a deuterated compound of Estriol. Estriol has a CAS number of 50-27-1. Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.

Estriol-D3 (Standard) is a reference standard of Estriol-D3 intended for quantitative analysis, quality control, and related biochemical research applications. Estriol-d3 is a deuterated compound of Estriol. Estriol has a CAS number of 50-27-1. Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.

Estrone-D2 (Standard) is a reference standard of Estrone-D2 intended for quantitative analysis, quality control, and related biochemical research applications. Estrone-d2 is a deuterated compound of Estrone. Estrone has a CAS number of 53-16-7. Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

Estrone-D4 (Standard) is a reference standard of Estrone-D4 intended for quantitative analysis, quality control, and related biochemical research applications. Estrone-d4 is a deuterated compound of Estrone. Estrone has a CAS number of 53-16-7. Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

17α-Ethynylestradiol-2,4,16,16-D4 (Standard) is a reference standard of 17α-Ethynylestradiol-2,4,16,16-D4 intended for quantitative analysis, quality control, and related biochemical research applications. 17α-Ethynylestradiol-2,4,16,16-d4 is a deuterated compound of 17α-Ethynylestradiol. 17α-Ethynylestradiol has a CAS number of 57-63-6. Ethinyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.

17β-Estradiol-16,16,17-d3 (Standard) is a reference standard of 17β-Estradiol-16,16,17-d3 intended for quantitative analysis, quality control, and related biochemical research applications. 17β-Estradiol-16,16,17-d3 is a deuterated compound of 17β-Estradiol. 17β-Estradiol has a CAS number of 50-28-2. Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.

17β-Estradiol-D4 (Standard) is a reference standard of 17β-Estradiol-D4 intended for quantitative analysis, quality control, and related biochemical research applications. 17β-estradiol-d4 is a deuterated compound of 17β-estradiol. 17β-estradiol has a CAS number of 50-28-2. Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.

17β-Estradiol-2,4,16,16,17-D5 (Standard) is a reference standard of 17β-Estradiol-2,4,16,16,17-D5 intended for quantitative analysis, quality control, and related biochemical research applications. 17β-Estradiol-2,4,16,16,17-d5 is a deuterated compound of 17β-Estradiol. 17β-Estradiol has a CAS number of 50-28-2. Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.