epirubicin

Epirubicin (4'-Epidoxorubicin) is an anthracycline antibiotic that acts as a Topoisomerase II inhibitor. It exerts its antitumor effects by intercalating into DNA base pairs, inhibiting DNA replication and transcription, and inducing DNA strand breaks/apoptosis. Epirubicin is widely used in the treatment of breast, gastric, lung, and ovarian cancers.

Epirubicin hydrochloride (Pharmorubicin) is an adriamycin derivative, a topoisomerase (Topo) inhibitor, and a Forkhead box protein p3 (Foxp3) inhibitor. Epirubicin hydrochloride has antitumor activity.

Epirubicinol is the 13-dihydro metabolite of Epirubicin. Epirubicin exhibits activity against various solid tumors and hematological malignancies, comparable to Doxorubicin.

4'-epi-Daunorubicin is the semisynthetic precursor to Epirubicin and functions as an antitumor agent.

NR-160 is a selective HDAC6 inhibitor (IC₅₀=30 nM) with low cytotoxicity against leukemia cell lines.

4'-epi-Daunorubicin hydrochloride is a key intermediate in the semisynthetic production of Daunorubicin Epirubicin.