enzyme

GSK1940029 (SCD inhibitor 1) is an inhibitor of stearoyl-CoA desaturase (SCD).

Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability metabolic activity.

Angiotensin-converting enzyme (Kininase II) is a zinc-dependent peptidase and extracellular enzyme that acts as a counterbalance to ACE in the renin-angiotensin system.Angiotensin-converting enzyme is a potent vasoconstrictor used in the study of cardiovascular and immune diseases. Angiotensin-converting enzyme is a potent vasoconstrictor used to study cardiovascular and immune diseases.

Enzyme-IN-3 disodium (compound 7) is a selective inhibitor of Mycobacterium tuberculosis shikimate kinase with an IC50 of 1.6 μM. Additionally, Enzyme-IN-3 disodium exhibits antibacterial properties.

Enzyme-IN-2 (compound 15) is a potent urease inhibitor, demonstrating anti-ureolytic activity with a K_i of 2.36 µM and an IC_50 of 0.75 µM [1].

Enzyme-IN-1 (compound 1), a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases, specifically targets and inhibits the chymotrypsin-like activity (CT-L) of the 20S proteasome. This compound may possess potential anti-inflammatory properties [1].

Alkaline Phosphatase is an ubiquitous membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values.

C1rEnzyme, the activated form of the C1r proenzyme, serves as an activator of Cls.

Coenzyme FO, a deazaflavin chromophore, is essential as a hydride acceptor donor in the central methanogenic pathway [1][2].

Coenzyme Q10 (CoQ10) (ubiquinone) is a naturally occurring compound, acting as the electron carrier in the mitochondrial respiratory chain.

Coenzyme A is an obligatory cofactor in all living cells synthesized from pantothenate (Vitamin B5), adenosine triphosphate (ATP), and cysteine.

Acyl coenzyme A synthetase (ACS), also known as acetyl coenzyme A synthetase, catalyzes the activation of fatty acids via coenzyme A through a two-step thioesterification process, forming acyl coenzyme A. It is crucial in anabolic and catabolic lipid metabolism pathways and contributes to the tricarboxylic acid (TCA) cycle during aerobic respiration [1].

Malonyl Coenzyme A lithium (Malonyl CoA lithium) is an important precursor for the production of a variety of chemicals that modulate insulin-stimulated glucose transport in myotubes.

Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such asPseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.1It is a precursor in the synthesis of the antibiotic penicillin G found in industrial strains ofP. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR inT. thermophilusand the GntR family transcriptional regulator PaaX inE. coliandPseudomonas, binding to each protein to induce derepression of various genes.2

Succinyl-Coenzyme A sodium salt(Succinyl-CoA sodium salt) participates in the citric acid cycle, where it is converted to succinic acid.Succinyl-Coenzyme A (sodium salt) is involved in a variety of metabolic reactions in living organisms, and plays an important role in the body.Succinyl-Coenzyme A (sodium salt) is involved in heme synthesis. Succinyl-Coenzyme A (sodium salt) is involved in the synthesis of hemoglobin and is used in the study of metabolic, neurological, and hematological disorders caused by nutritional vitamin B12 deficiency, which results in a deficiency in Succinyl-Coenzyme A synthesis.

Octanoyl coenzyme A triammonium, a medium-chain acyl coenzyme A, can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC50 values of 0.4-1.6 mM [1].

Coenzyme Q8 (Ubiquinone 8) is an isoprenoid quinone isolated from the plasma membrane of wild-type or long-lived qm30 and qm51 clk-1 mutant strains of Cryptomeria cepacia that mediates electron transfer in the aerobic respiratory chain and reduces oxidative stress.

Acetoacetyl coenzyme A sodium, a pivotal endogenous metabolite, exhibits a K m of 1.10 mM at pH 7.5 and plays a crucial role in the synthesis of phosphotransbutyrylase (PTB) and poly-3-hydroxybutyrate (PHB) [1] [2].

Acetyl-coenzyme A (Acetyl-CoA), a membrane-impermeant central metabolic intermediate, plays a crucial role in the TCA cycle and oxidative phosphorylation metabolism. It also serves as the sole donor of acetyl groups for post-translational acetylation of protein target amino acid residues, regulating various cellular mechanisms. Additionally, Acetyl-CoA is a vital precursor in lipid synthesis [1] [2] [3] [4].

Coenzyme Q0 (CoQ0), a potent, orally active ubiquinone compound derived from Antrodia cinnamomea, induces apoptosis and autophagy. It suppresses HER-2 AKT mTOR signaling, enhancing apoptosis and autophagy mechanisms. Additionally, Coenzyme Q0 regulates NFκB AP-1 activation and promotes Nrf2 stabilization, contributing to the attenuation of inflammation and redox imbalance. It also exhibits anti-angiogenic activity by downregulating MMP-9 NF-κB and upregulating HO-1 signaling.

Octanoyl coenzyme A lithium, a derivative of fatty acid acyl coenzyme A, inhibits citrate synthase and glutamate dehydrogenase (IC50: 0.4-1.6 mM).

β-Methylcrotonyl coenzyme A lithium, a key intermediate in leucine metabolism, serves as a substrate to investigate the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase) [1].

Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD). Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase.

Coenzyme Q10 is a vitamin-like substance found throughout the body, especially in the heart, liver, kidneys, and pancreas.