endocrine-disrupting

Triclocarban (Cutisan), an antimicrobial agent, is used in personal cleaning products.

Bisphenol A is an endogenous metabolic compound of phenols and is widely used in the production of epoxy resins and polycarbonate plastics. It is reproductive, developmental and systemic toxicant and is often classified as an endocrine disruptor. It has been linked to many diseases, including respiratory disease, cardiovascular disease, diabetes, kidney disease, obesity and reproductive disorders.

Oxybenzone is a UV filter commonly used in tanning and skin protection agents. It is a derivative of benzophenone and is used as an endocrine disrupting chemical that penetrates the placental and blood-brain barriers. It impairs autophagy, alters epigenetic status and disrupts vitamin X-like receptor signaling in apoptotic neuronal cells.

4-tert-Octylphenol, an endocrine-disrupting chemical with estrogenic properties, notably induces apoptosis in offspring mouse brain neuronal progenitor cells. This compound decreases levels of bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), thereby diminishing the proliferation of neuronal progenitors. Consequently, 4-tert-Octylphenol adversely affects brain development and behavior in mice.

4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway.

Dibenzyl phthalate is an endocrine-disrupting chemical. It also interferes with different cell signaling pathways involved in weight and glucose homeostasis.

Triphenyl phosphate is an organophosphorus flame retardant and endocrine disruptor that activates MAO-A/ROS/NF-κB pathways, disrupting placental tryptophan metabolism and inducing abnormal neurobehavioral effects. It also promotes oxidative stress via inflammatory mediators including NF-κB, IL-6, and TNF-α.

Bisphenol B-D8 isphenol B-D8 is the deuterated form of Bisphenol B, which is structurally similar to Bisphenol A. Bisphenol A is known as an endocrine disrupting chemical (EDC). Additionally, Bisphenol B (T5624) exhibits endocrine-disrupting or other harmful effects in animal models.

Oxybenzone-D3 is a deuterium-labeled form of Oxybenzone. Commonly used as a UV filter in tanning and skin protection products, Oxybenzone (T0499) (Benzophenone 3) acts as an endocrine-disrupting chemical (EDC) that can cross both the placental and blood-brain barriers. It impairs autophagy, alters epigenetic states, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.

Oxybenzone-13C6 is the 13C-labeled version of Oxybenzone. This compound, also known as Benzophenone 3, is commonly utilized as a UV filter in tanning and skin protection products. Oxybenzone (T0499) is an endocrine-disrupting chemical (EDC) capable of crossing the placental and blood-brain barriers. It impairs autophagy, alters the epigenetic state, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.

Linuron, a substituted phenylurea herbicide, primarily functions by disrupting the photosynthetic process through the inhibition of photosystem II. it additionally acts as an androgen receptor antagonist, exhibiting endocrine-disrupting effects and reproductive toxicity, Maternal linuron exposure alters testicular development in male offspring at the whole genome level and significantly altering expressions of key testosterone synthesis-associated genes including Star, P450scc, 3β-Hsd, Abp, Cox7a2, Pcna, p450c17, and 17β-Hsd.

7-Oxodehydroabietic acid is a diterpene resin acid located in the roots of Pinus densiflora (pine), functioning as a defensive agent against herbivorous insects by disrupting their endocrine systems.

Triticonazole is a triazole pesticide and fungicide. Triticonazole shows endocrine disrupting activities.

4-Nonylphenol-D5 is a deuterated label of 4-n-nonylphenol for isotope tracing. 4-n-Nonylphenol is the primary degradation product of nonylphenol ethoxylates (NPEOs), exhibiting endocrine-disrupting properties and weak estrogenic activity.

Bisphenol A-D14 is a deuterium-labeled variant of Bisphenol A (T5623). Bisphenol A, an organic synthetic compound in the phenol class, is commonly utilized in the production of polycarbonate plastics and epoxy resins. It is recognized for its reproductive, developmental, and systemic toxicity and is often classified as an endocrine-disrupting chemical (EDC). This compound is associated with various diseases, including cardiovascular conditions, respiratory issues, diabetes, kidney diseases, obesity, and reproductive disorders.

Bisphenol A-D6 isphenol A-D6 is a deuterated form of Bisphenol A (T5623) (BPA), which is an aromatic organic compound commonly used in the production of polycarbonate plastics and epoxy resins. BPA is recognized as a reproductive, developmental, and systemic toxicant, often categorized as an endocrine-disrupting chemical (EDC). It is associated with various health issues, including cardiovascular, respiratory, diabetic, renal, obesity-related, and reproductive disorders.

4-Octylphenol (Standard) is the standard substance of 4-Octylphenol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway.

4-tert-Octylphenol (Standard) is the standard substance of 4-tert-Octylphenol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 4-tert-Octylphenol, an endocrine-disrupting chemical with estrogenic properties, notably induces apoptosis in offspring mouse brain neuronal progenitor cells. This compound decreases levels of bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), thereby diminishing the proliferation of neuronal progenitors. Consequently, 4-tert-Octylphenol adversely affects brain development and behavior in mice.

Oxybenzone (Standard) is the standard substance of Oxybenzone, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Oxybenzone is a UV filter commonly used in tanning and skin protection agents. It is a derivative of benzophenone and is used as an endocrine disrupting chemical that penetrates the placental and blood-brain barriers. It impairs autophagy, alters epigenetic status and disrupts vitamin X-like receptor signaling in apoptotic neuronal cells.

Triticonazole (Standard) is the standard substance of Triticonazole, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Triticonazole is a triazole pesticide and fungicide. Triticonazole shows endocrine disrupting activities.

4-Nonylphenol-D5 (Standard) is a reference standard of 4-Nonylphenol-D5 intended for quantitative analysis, quality control, and related biochemical research applications. 4-Nonylphenol-d5 is a deuterated label of 4-n-nonylphenol for isotope tracing. 4-n-Nonylphenol is the primary degradation product of nonylphenol ethoxylates (NPEOs), exhibiting endocrine-disrupting properties and weak estrogenic activity.

Mono (4-methyl-7-hydroxyoctyl) phthalate (OH-MINP) is an endocrine-disrupting compound.