eclipta alba

Wedelolactone (IKK Inhibitor II) is a natural product derived from Eclipta prostrata that inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα, and exhibits anticancer, anti-inflammatory, and antioxidant activities. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells by downregulating PKCε, without inhibiting Akt. Wedelolactone inhibits 5-Lox with an IC50 value of 2.5 μM. Wedelolactone can be used in research on inflammation, tumors, liver disease, and immune-related diseases.

Isodemethylwedelolactone (Isodemethylwedelolacton) is a natual product,has Clotting activity.

Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.