ebastine

Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tissue without a central side effect, i. e not causing sedation or drowsiness.

Hydroxy Ebastine is an ebastine metabolite. Ebastine undergoes rapid first-pass metabolism by the cytochrome P450 isoform CYP2J2 to form hydroxy ebastine which is then metabolized by CYP2J2 and CYP3A4 to form carebastine.

Ebastine (Standard) is the standard substance of Ebastine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tissue without a central side effect, i. e not causing sedation or drowsiness.

Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor.