diterpenoids

Geranylgeranyl pyrophosphate tetrabutylammonium(1:2) is one of the endogenous cholesterol and intermediates produced by the mevalerate pathway. Geranylgeranyl pyrophosphate tetrabutylammonium(1:2) is the common precursor of diterpenoids, for example, Paclitaxel. It can be used for cancer research.

Farnesylacetone ((5E,9E)-6,10,14-Trimethylpentadeca-5,9,13-trien-2-one) is a marine derived natural products found in Sargassum micracanthum.

(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium floribundum. It potently inhibits osteoclastogenesis and facilitates bone healing and increased bone mass through osteoblast differentiation, mediated by the estrogen receptor (ER) β.

Kaurane-3,16,17-triol,ent-kaurane-3-oxo-16α,17-diol,and ent-16α,17-dihydroxyatisan- 3-one are three kinds of toxic diterpenoids isolated from the roots of genus Euphorbia.

Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucose transport in rat adipocyte plasma membranes.2Deactylforskolin (30-1,000 μg/kg) reduces blood pressure in spontaneously hypertensive rats.3It also attenuates hypercapnia-induced impairments in the passive avoidance response in mice.4 1.Gabetta, B., Zini, G., and Danieli, B.Minor Diterpenoids of Coleus forskohliiPhytochemistry28(3)859-862(1989) 2.Joost, H.G., Habberfield, A.D., Simpson, I.A., et al.Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of actionMol. Pharmacol.33(4)449-453(1988) 3.Bhat, S.V., Dohadwalla, A.N., Bajwa, B.S., et al.The antihypertensive and positive inotropic diterpene forskolin: Effects of structural modifications on its activityJ. Med. Chem.26(4)486-492(1983) 4.McCulloch, A.J., Thomson, T.A., and Deacon, R.Hypoxic amnesia and its reversal with forskolinBiochem. Soc. Trans.17(1)212-213(1988)

Minimolide F, isolated from Centipeda minima, shows antiproliferative activity against human nasopharyngeal cancer cells with an IC50 of 17.4 μM.

Lasiodonin is a natural product isolated from the leaves of Isodon parvifolius.

Pseudolaric acid B β-D-glucoside (Pseudolaric acid B-glucopyranoside) is a natural product derived from Pseudolarix amabilis.

Methyl dodonate A acetate is a natural product for research related to life sciences. The catalog number is TN4541 and the CAS number is 349487-98-5.

ent-11β-Hydroxyatis-16-ene-3,14-dione, identified by catalog number TN3933 and CAS number 1092103-22-4, is a natural product used for research in life sciences.

7-Epi-10-deacetylcephalomannine is a natural product from Taxus sumatrana.

Ingenol-5,20-acetonide-3-O-angelate (Ingenol 5,20-acetonide 3-angelate) is a natural product.

Lophotoxin belongs to the cembrene class of diterpenoids; neuromuscular toxin isolated from several pacific gorgonians of the genus Lophogorgia.

Longikaurin E ((-)-Longikaurin E) is a therapeutic agent for pancreatic cancer. It is isolated from Isodon adenolomus.

Chinensine B and Chinensines A, C, D and Ε are antitumor diterpenoids.

Geranylgeranyl pyrophosphate, a key metabolite in protein geranylgeranylation, serves as the universal precursor for diterpenoids, such as Paclitaxel. Its role in cancer research stems from this critical function.

Lophanthoidin B is a natural product isolated from the herbs of Rabdosia lophanthoides.

Lophanthoidin F is a kind of natural product derived from the herbs of Rabdosia lophanthoides.

Eurycomanol 2-O-β-D-glucopyranoside, a natural diterpenoid compound, is extracted from Tongkat Ali.

Taxachitriene A is a natural product from the Chinese yew Taxus chinensis.

7-Xylosyltaxol B is a natural product from Taxus wallichiana var.mairei.

6alpha-Hydroxynidorellol is a natural product from Callicarpa macrophylla.

Totarol ((+)-Totarol) shows antibacterial effects against several pathogenic Gram-positive bacteria, mycobacterium tuberculosis.

Pristane (2,6,10,14-tetramethylpentadecane) is a natural product from shark liver oil and a non-antigenic adjuvant.