digitoxigenin

Digitoxigenin is a precursor of cardiac glycosides that acts by targeting the metastatic uveal melanoma gene signature.

Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.

3-epi-Digitoxigenin is a triterpene extracted from the foliage and stems of Plumeria [frangipani].

Digitoxigenin-3-O-β-D-quinovoside, a cardiac lactone extracted from Elaeodendron australe var. integrifolium, serves as an interleukin-2 (IL-2)/luciferase inhibitor, demonstrating an inhibitory concentration (IC 50) of 52 nM.

14-Anhydrodigitoxigenin is a cardenolide and a derivative of digitoxin.1 It reduces the activity of guinea pig heart Na+/K+-ATPase by 15% when used at a concentration of 10 μM.2

8-Hydroxydigitoxigenin is a natural product of Nerium, Apocynaceae. The catalog number is TN5291 and the CAS number is 1049674-06-7. 8-Hydroxydigitoxigenin can be used as a reference standard.

PST2286 (17-Hydroxydigitoxigenin) is a rostafuroxin metabolite.

1. Periplogenin (Desoxostrophanthidin) plays protective roles against thyrotoxicosis and associated cardiovascular problems, are mediated through its direct antithyroidal and/or LPO inhibiting properties.

Periplogenin-KLH is a hapten-carrier protein conjugate formed by coupling Periplogenin to keyhole limpet hemocyanin (KLH). As a hapten, Periplogenin alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. Periplogenin-KLH may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M TBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

Periplogenin-BSA is a hapten-carrier protein conjugate formed by coupling Periplogenin to bovine serum albumin (BSA). As a hapten, Periplogenin alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. Periplogenin-BSA may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M TBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

Thevebioside and digitoxin are cardiac glycosides, have cardiac action.