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Cat No. | Product Name | Synonyms | Targets |
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T10096L | Voruciclib | CDK | |
Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the ... | |||
T16040 | Mepazine | Pecazine | Apoptosis , MALT |
Mepazine (Pecazine) is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability. | |||
T3549 | Avadomide | CC 122 | Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase |
Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity. | |||
T1944 | LDN-214117 | ALK , TGF-beta/Smad | |
LDN-214117 is a potent and selective ALK2 inhibitor. | |||
T14367 | AZ1495 | IRAK , CDK , Haspin Kinase | |
AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffu... | |||
T5354 | IRAK4-IN-7 | CA-4948 | IRAK |
IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model. | |||
T60008 | BCL6-IN-6 | BCL | |
BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressors and dose-dependently reactivates Bcl-6 target genes. | |||
T77135 | Tafasitamab | MOR00208,XmAb5574,Tafasitamab-cxix | Apoptosis , Immunology/Inflammation related |
Tafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell lymphoma. | |||
T77367 | Urelumab | BMS-663513,BMS-66513 | Others |
Urelumab(BMS-66513) is a humanized IgG4 monoclonal antibody, often used as a CD137 agonist.Urelumab has potential antitumor activity, potentiating tumor cell killing by T-cells and natural killer cells, and enhancing the... | |||
T9969 | EZM0414 | Histone Methyltransferase | |
EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay. EZM0414 can be used for the research of relapsed or refractory m... | |||
T23409 | FM4-64 | SynaptoRedTM C2 | Others |
FM4-64 (SynaptoRedTM C2) is a styryl dye that stains stably but does not fluoresce in aqueous solution.FM4-64 does not passively diffuse into the plasma membrane bilayer and must be actively transported across the membra... | |||
T76776 | Emactuzumab | RO 5509554,RG 7155 | c-Fms , TAM Receptor |
Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has antitumor activity and inhibits activation of colony-stimulating fa... | |||
T10529 | BF-168 | Others | |
BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42). | |||
T25400 | EZH2-IN-3 | EZH2 inhibitor 3,EZH2-inhibitor-3 | |
EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth. | |||
T76946 | Zuberitamab | ||
Zuberitamab (HS006) is a monoclonal antibody targeting CD20, utilized in cancer research, notably in diffuse large B-cell lymphoma [1]. | |||
T40901 | Aderbasib | INCB007839,INCB7839 | |
Aderbasib (INCB007839) is a highly potent and orally active hydroxamate-based inhibitor of ADAM10 and ADAM17, with low nanomolar affinity. This compound demonstrates strong antineoplastic activity and holds potential for... | |||
T77940 | Tazemetostat de(methyl morpholine)-COOH | Ligands for Target Protein for PROTAC | |
Tazemetostat de(methyl morpholine)-COOH (compound 7), a PROTAC ligand for EZH2, facilitates the synthesis of PROTACs that target this enzyme. These EZH2 degraders exhibit potent inhibition of cell viability in diffuse la... | |||
T81696 | NBI-961 | ||
NBI-961, a potent NEK2 inhibitor, suppresses proteasomal degradation and effectively induces G2/mitosis arrest and apoptosis within diffuse large B cell lymphoma (DLBCL) cells [1]. | |||
T11674 | IRAK4-IN-6 | Others | |
IRAK4-IN-6 is a selective and orally efficacious inhibitor of IRAK4, demonstrating an IC50 value of 4 nM. This compound specifically targets MyD88 L265P mutant diffuse large B-cell lymphoma [1]. | |||
T77070 | Loncastuximab | ||
Loncastuximab (RB4v1.2), an anti-CD19 monoclonal antibody, exhibits antitumor properties and holds potential for treating non-Hodgkin's lymphoma (NHL), specifically diffuse large B-cell lymphoma (DLBCL) [1] [2]. | |||
T78877 | MTX-241F | EGFR | |
MTX-241F, a selective small molecule inhibitor, targets members of the EGFR and PI3 kinase families. It penetrates the blood-brain barrier, providing long-term tumor growth control and exhibits radiosensitizing activity ... | |||
T80981 | Tisagenlecleucel | CTL019 | |
Tisagenlecleucel (CTL019), an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, selectively targets and eradicates CD19-expressing B cells, and is utilized in the study of refractory aggressive diffuse... | |||
T62403 | DM-01 | ||
DM-01 is a potent and selective inhibitor of EZH2. DM-01 can be used to study diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and SNF5/INI-1/SMARCB1 gene-associated solid tumours. | |||
T73093 | Z-VRPR-FMK | ||
Z-VRPR-FMK, an irreversible inhibitor of the MALT1 protein, effectively suppresses the proliferation and invasion of diffuse large B-cell lymphoma. This is achieved through the inhibition of MALT1-induced NF-κB activatio... | |||
T26688 | Avadomide HCl | Avadomide hydrochloride,CC122, Avadomide HCl,CC-122,CC 122 HCl | |
Avadomide is an orally available pleiotropic pathway modulator with potential antineoplastic activity. CC-122 mimics an interferon response and has antitumor activity in DLBCL CC-122 binds Cereblon (CRBN) and promotes de... | |||
T73869 | BCL6 PROTAC 1 | ||
BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) proteolysis targeting chimera (PROTAC) that inhibits the BCL6 cell reporter with an IC50 value of 8.8 µM and significantly degrades BCL6 in diffuse large B-cell lymph... | |||
T79485 | IRAK4-IN-27 | IRAK | |
IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) c... | |||
T76854 | Loncastuximab tesirine | ||
Loncastuximab tesirine, a human cluster of differentiation 19 (CD19)-directed antibody-drug conjugate (ADC), binds to CD19 on the cell membrane, facilitating rapid internalization and inducing cell apoptosis. This mechan... | |||
T76393 | Amyloid 17-42 | ||
Amyloid 17-42 (Aβ(17-42)), a significant component of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, results from the alpha- and gamma-secretase cleavage of amyloid precursor protei... | |||
T62109 | HDAC-IN-31 | ||
HDAC-IN-31 is a selective, potent, orally active HDAC inhibitor that acts on HDAC1 (IC50: 84.90 nM), HDAC2 (IC50: 168.0 nM), HDAC3 (IC50: 442.7 nM), HDAC8 (IC50>10000 nM). HDAC-IN-31 has good anti-tumour effects. HDAC-IN... | |||
T79801 | TCIP 1 | Epigenetic Reader Domain | |
TCIP 1 is a small molecule in the category of transcriptional/epigenetic covalent inhibitor probes (TCIPs) that forms covalent bonds with molecules targeting BCL6 and BRD4. This compound facilitates cell death gene expre... | |||
TP2182 | Lamin fragment | Others | |
Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp. Lamin polypeptides have an almost complete α-helical conformation with multiple α-helical domains separated by non-α-helical linkers that are ... | |||
T60488 | Ganciclovir hydrate | ||
Ganciclovir (BW 759) hydrate is a nucleoside analogue that is an orally active antiviral agent with anti-cytomegalovirus activity. Ganciclovir hydrate is also active against members of the herpes group and some other DNA... | |||
T37743 | N-octadecanoyl-L-Homoserine lactone | ||
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm forma... | |||
T37741 | N-hexadecanoyl-L-Homoserine lactone | C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone | |
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm fo... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5598 | Cis-3-Hexenyl hexanoate | Others | |
cis-3-Hexenyl hexanoate, existing in some fruit, has strong diffuse fruit aroma. | |||
T20173 | Noradrenaline tartrate | NSC 169106,NSC-169106,l-Noradrenaline d-bitartrate,NSC169106,Norepinephrine bitartrate | |
Norepinephrine bitartrate is a precursor of epinephrine. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceru... | |||
T40634 | Perilla ketone | ||
Perilla ketone is a naturally occurring xenobiotic compound that undergoes activation by pulmonary P450 cytochrome enzymes within the lung. This activation leads to the manifestation of severe pulmonary damage and the de... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03762 | E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadher... | |||
TMPY-02512 | Alpha-Synuclein Protein, Human, Recombinant | Human | E. coli |
Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associate... | |||
TMPH-00267 | GJD2 Protein, Bovine, Recombinant (His & SUMO) | Bovine | in vitro E. coli expression system |
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | |||
TMPH-01373 | GJA5 Protein, Human, Recombinant (His) | Human | E. coli |
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | |||
TMPH-01372 | GJA1 Protein, Human, Recombinant (His) | Human | E. coli |
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one... | |||
TMPY-02430 | BCL6 Protein, Human, Recombinant (aa 1-150, His & Trx) | Human | E. coli |
The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexe... | |||
TMPH-02669 | GJA1 Protein, Mouse, Recombinant (His & Myc) | Mouse | Baculovirus |
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one... | |||
TMPY-03667 | SLAM/CD150 Protein, Rat, Recombinant (His) | Rat | HEK293 |
CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is exp... | |||
TMPY-00627 | SLAM/CD150 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is exp... | |||
TMPH-02360 | Influenza B (strain B/Lee/1940) Nucleoprotein/NP Protein (His) | Influenza B | Yeast |
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l... | |||
TMPH-02353 | Influenza A H1N1 (strain A/Fort Warren/1/1950) Nucleoprotein/NP Protein (His & SUMO) | H1N1 | E. coli |
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l... | |||
TMPY-06318 | Alpha-Synuclein Protein,Human,Recombinant (H50Q) | Human | E. coli |
Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associate... | |||
TMPY-02137 | E-Cadherin/Cadherin-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadher... | |||
TMPY-02129 | Transglutaminase 3/TGM3 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Transglutaminases (TGase) are a family of calcium-dependent acyl-transfer enzymes ubiquitously expressed in mammalian cells and responsible for catalyzing covalent cross-links between proteins or peptides. Transglutamina... | |||
TMPH-02354 | Influenza A H1N1 (strain A/New Jersey/8/1976) Nucleoprotein/NP Protein (His & SUMO) | H1N1 | E. coli |
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l... | |||
TMPH-02362 | Influenza B (strain B/Singapore/222/1979) Nucleoprotein/NP Protein (His & SUMO) | Influenza B | E. coli |
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l... | |||
TMPH-02355 | Influenza A H3N2 (strain A/Port Chalmers/1/1973) Nucleoprotein/NP Protein (His & SUMO) | H3N2 | E. coli |
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l... | |||
TMPH-02361 | Influenza B (strain B/Lee/1940) Nucleoprotein/NP Protein (His & SUMO) | Influenza B | E. coli |
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l... | |||
TMPH-02350 | Influenza A H3N2 (strain A/Shanghai/16/1989) Nucleoprotein/NP Protein (His) | H3N2 | E. coli |
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l... | |||
TMPJ-01337 | IL-21R Protein, Mouse, Recombinant (aa 20-236, His) | Mouse | Human Cells |
Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. IL-21R is expressed mainly on B cells, NK cells, and activated T cells, but is also f... | |||
TMPY-01016 | SLAM/CD150 Protein, Human, Recombinant (His) | Human | HEK293 |
CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is exp... | |||
TMPH-02351 | Influenza A H3N2 (strain A/Beijing/353/1989) Nucleoprotein/NP Protein (His & SUMO) | H3N2 | E. coli |
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l... | |||
TMPH-02352 | Influenza A H3N2 (strain A/Kitakyushu/159/1993) Nucleoprotein/NP Protein (His) | H3N2 | E. coli |
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l... | |||
TMPY-04041 | E-Cadherin/Cadherin-1 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadher... | |||
TMPY-03244 | E-Cadherin/Cadherin-1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadher... | |||
TMPY-03986 | PIST Protein, Human, Recombinant (His) | Human | E. coli |
GOPC, also known as PIST, interacts specifically with TC1 (a Rho-family small GTPase)] as a binding partner for Rhotekin. Rhotekin associates with PIST in vitro and both polarized and non-polarized MDCK (Madin-Darby cani... | |||
TMPY-05656 | E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc), Biotinylated | Human | HEK293 |
Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadher... | |||
TMPY-06460 | Alpha-Synuclein Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associate... | |||
TMPY-05052 | E-Cadherin/Cadherin-1 Protein, Human, Recombinant (His) | Human | HEK293 |
Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadher... | |||
TMPY-02331 | UCHL1 Protein, Rat, Recombinant (His) | Rat | E. coli |
Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, Ubiquitin thioesterase L1, PGP9.5 and UCHL1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis b... | |||
TMPY-02175 | UCHL1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, Ubiquitin thioesterase L1, PGP9.5 and UCHL1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis b... | |||
TMPY-01547 | UCHL1 Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, Ubiquitin thioesterase L1, PGP9.5 and UCHL1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis b... | |||
TMPY-02063 | Alpha-2-macroglobulin Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
alpha-2-macroglobulin, also known as α2-macroglobulin (α2M and A2M), is an abundant protein of the plasma of vertebrates and members of several invertebrate phyla and functions as a broad-spectrum protease-binding protei... |