dicentrine,

Dicentrine, (-)- (NSC-251699) is an aporphinic alkaloid found in several plant species, which showed significant antinociceptive activity in an acute model of visceral pain in mice.

Dicentrine is an alkaloid-enriched fraction and the primary alkaloid of the leaves of Ocotea puberula (Lauraceae), a native Brazilian plant traditionally used by Indigenous populations for skin affections, and dicentrine further demonstrates pharmacological activity as an α1-adrenoceptor antagonist in human hyperplastic prostate tissue. Dicentrine has been evaluated using radioligand binding assays with [3H]prazosin and in vitro isometric tension experiments, confirming functional α1-adrenoceptor involvement and supporting therapeutic relevance in disorders associated with prostate hyperplasia.

Neolitsine has anthelmintic activity, it exhibits EC90 values (concentration at which 90% loss of larval motility is observed) of 6.4 microg/mL.Neolitsine and dicentrine have potent vasorelaxing effects on precontracted rat aortic preparations with mean IC 50 values between 0.08 and 2.48 microM.