deoxynucleoside

IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.

5'-O-DMT-N2-ibu-dG is a deoxynucleoside used in the preparation of oligonucleotides, served as a building block in oligonucleotide synthesis, with protecting groups to prevent unwanted reactions during synthesis.

Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.

5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7) is a deoxynucleoside used in synthesizing dodecyl phosphoramidite, a crucial precursor for dod-DNA production. Dod-DNA is amphiphilic DNA with dodecyl phosphotriester linkages, featuring an internal hydrophobic region[1][2].

Clevudine triphosphate is a TTP analog that is able to inhibit protein priming independently of the deoxynucleoside triphosphate substrate.

Sp-2'-Deoxycytidine-5'-O-(1-thiotriphosphate) (Sp-dCTP-α-S), an isomer of the sulfur-containing nucleotide derivative dCTP-α-S, functions as an inhibitor of the deoxynucleoside triphosphate triphosphohydrolase SAMHD1, with an inhibition constant (Ki) of 6.3 µM.

Sp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate), a sulfur-containing isomer of 2'-deoxyguanosine-5'-O-triphosphate (dGTP), functions as an inhibitor of the deoxynucleoside triphosphate triphosphohydrolase SAMHD1, with an inhibitory constant (Ki) of 820 nM.

Sp-Thymidine-5'-O-(1-thiotriphosphate) (Sp-TTP-α-S), an isomer of the sulfur-containing nucleotide derivative TTP-α-S, exhibits affinity for HIV-1 reverse transcriptase with dissociation constants (Kds) of 2.88, 4.23, and 20.21 µM in the presence of magnesium, manganate, and cobalt, respectively. Additionally, Sp-TTP-α-S effectively inhibits the enzyme deoxynucleoside triphosphate triphosphohydrolase SAMHD1 with an inhibition constant (Ki) of 46 nM.

3′-Azido-ddATP sodium is a labeled and modified deoxynucleoside triphosphate (dNTP) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.This product is commonly used in pyrophosphate sequencing or high-sensitivity enzyme-linked assays.

AZT triphosphate sodium is a labeled and modified deoxynucleoside triphosphate (dNTP) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.

dATPαS sodium is a labeled and modified deoxynucleoside triphosphate (dNTP) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.

2'-Deoxycytidine-13C9 is the 13C-labeled version of 2'-Deoxycytidine (TMSM-0174). This deoxynucleoside has the capability to inhibit the biological activity of Brdu.

2'-Deoxycytidine-13C9,15N3 is a 2'-Deoxycytidine (T4758) labeled with isotopes 13C and 15N. This deoxynucleoside can inhibit the bioactivity of BrdU.

2'-Deoxycytidine-15N3 is a 15N-labeled form of 2'-Deoxycytidine (TMSM-0174). This deoxynucleoside has the capability to inhibit the biological activity of BrdU.

2'-Deoxynucleoside,2/6/8-Modified nucleoside

Nucleosides - 2'-deoxynucleoside

8-Bromo-2'-deoxyguanosine is a 2'-deoxynucleoside and a halo-nucleoside.

8-Bromo-2'-deoxyadenosine is a 2'-deoxynucleoside and halo-nucleoside.

AcycloCTP sodium is a labeled and modified deoxynucleoside triphosphate (dNTP) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.

3'-ONH2-dCTP (sodium) solution (100mM) is a labeled and modified deoxynucleoside triphosphate (dNTP) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.

3′-O-Azidomethyl-dATP sodium solution (100mM) is a labeled and modified deoxynucleoside triphosphate (dNTP) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.

5-CF3-ddUTP sodium is a labeled and modified deoxynucleoside triphosphate (dNTP) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.

3′-Azido-ddGTP sodium is a labeled and modified deoxynucleoside triphosphate (dNTP) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.

3′-Azido-ddCTP sodium is a labeled and modified deoxynucleoside triphosphate (dNTP) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.