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  • Epigenetic Reader Domain
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dbet1

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  • Inhibitors & Agonists
    4
    TargetMol | Inhibitors_Agonists
  • PROTAC Products
    4
    TargetMol | PROTAC
dBET1
T44951799711-21-9
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.
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Hyp-dBET1
T206198
Hyp-dBET1 is a PROTAC degrader targeting BRD4, with an IC50 value of 3.4 μM in MDA-MB-231 cells. Under hypoxic conditions, Hyp-dBET1 becomes active, recruiting E3 ubiquitin ligase, and facilitates the degradation of BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable in anti-cancer research.
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Cath-L-dBET1
T206243
Cath-L-dBET1 is a PROTAC degrader targeting BRD4. It has an IC50 value of 2.8 μM in MDA-MB-231 cells. Activated by cathepsin L (Cath-L), Cath-L-dBET1 recruits E3 ubiquitin ligase to degrade BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable for antitumor research.
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DAO-dBET1
T206694
DAO-dBET1, a dual-action PROTAC incorporating the PROTAC degrader dBET1, effectively serves as a potent BRD4 degrader and exhibits a DC50 value of 277 nM in the presence of CoCl2. Additionally, DAO-dBET1 inhibits hypoxia and Cath-L activation with an IC50 value of 281 nM.
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