dabigatran

Dabigatran (BIBR 953ZW) is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.

Dabigatran-D4 hydrochloride is deuterium-labeled dabigatran, which is a reversible and selective direct thrombin inhibitor (DTI) with a Ki value of 4.5 nM.

Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a thrombin inhibitor.

Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.

Dabigatran acyl-β-D-glucuronide, an active metabolite of the thrombin inhibitor dabigatran, is synthesized predominantly through the action of the UDP-glucuronosyltransferase isoform UGT2B15. This compound, at a concentration of 0.46 µM, effectively prolongs activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.

Dabigatranimpurity 29 (Dabigatran impurity F) is a known impurity of Dabigatran.

Dabigatran impurity 1 (Dabigatran Carboxamide) is an impurity of Dabigatran.

Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor that binds to thrombin, blocking its thrombogenic activity and preventing thrombus formation.

Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM).

Dabigatran ethyl ester (Dabigatran (ethyl ester)) is an emerging oral anticoagulant and it also is a direct inhibitor of thrombin activity.

N-Nitroso-dabigatran etexilate-13C6 (Dabigatran impurity 95-13C6) is a 13C-labeled version of N-Nitroso-dabigatran etexilate.

Dabigatran-13C6 (Standard) is a reference standard of Dabigatran-13C6 intended for quantitative analysis, quality control, and related biochemical research applications. Dabigatran-13C6 is the 13C labeled compound of Dabigatran. Dabigatran has a CAS number of 211914-51-1. Dabigatran is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.

Dabigatran-D4 Hydrochloride (Standard) is a reference standard of Dabigatran-D4 Hydrochloride intended for quantitative analysis, quality control, and related biochemical research applications. Dabigatran-d4 Hydrochloride is a deuterated compound of Dabigatran Hydrochloride. Dabigatran Hydrochloride has a CAS number of 1019206-66-6.

BIBR 1087 SE (Desethyl Dabigatran Etexilate) is a metabolite of dabigatran etexilate.

Dabigatran-D4 hydrochloride is a deuterated compound of Dabigatran hydrochloride (TMSM-3464). Dabigatran hydrochloride has a CAS number of 211914-51-1. Dabigatran is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.

Dabigatran-D3 is a deuterated compound of Dabigatran (TMSM-3464).

Dabigatran acyl-β-D-glucuronide-13C6 is the 13C-labeled version of Dabigatran acyl-β-D-glucuronide.

Dabigatran impurity 75 is a constituent impurity of Dabigatran.

Dabigatran impurity 4 is an impurity of Dabigatran.

Dabigatran impurity 52 is a type of impurity found in Dabigatran.

Dabigatran Impurity 14 hydrochloride is an impurity of Dabigatran.

Dabigatran impurity 43 is an impurity associated with Dabigatran.

Dabigatran impurity 45 is an impurity associated with Dabigatran.

Dabigatran impurity 80 is an impurity of Dabigatran.