cyclocreatine

Cyclocreatine, a Creatine analogue, exhibits potent bioenergetic protection by elevating ATP levels. It demonstrates the ability to traverse cell membranes, including the blood-brain barrier, wherein it undergoes phosphorylation and dephosphorylation by creatine kinases.

Cyclocreatine phosphate (CCrP) is an anti-tumor agent and the proposed active form of cyclocreatine (CCr), a substrate analogue of creatine kinase. As potent cardioprotective drugs, cyclocreatine and its water-soluble derivative CCrP can be used for cancer research[1].