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Results for "
cs 038
" in TargetMol Product Catalog- Inhibitors & Agonists1
Relutrigine
PRAX-562
T696522392951-29-8
Relutrigine (PRAX-562), an orally active persistent sodium channel inhibitor, potently and selectively targets persistent I Na, induced either by ATX-II (Nav 1.5 activator) or SCN8A mutation N1768D, with IC 50 values of 141 nM and 75 nM, respectively. Demonstrating a potent use-dependent block, it effectively reduces neuronal intrinsic excitability and exhibits significant anticonvulsant activity.
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