cross-link

Cross-linked dextran G 200 is a hydrophilic gel designed for the separation of macromolecules based on molecular size exclusion. It operates through a gel permeation mechanism; its cross-linked structure forms a three-dimensional network with specific pore sizes, facilitating separation according to the hydrodynamic volume of molecules. This compound is utilized to regulate the partition coefficient of permeating solutes and maintain osmotic balance, and is commonly applied in gel filtration chromatography for the purification and analysis of biomacromolecules like proteins and nucleic acids. Additionally, Cross-linked dextran G 200 serves as a gel filtration medium (particle size range: 40-120 μm; spherical protein separation range: 5k-600k Da).

Cross-linked dextran G 150 is a hydrophilic gel used as a gel filtration medium, with a particle size range of 40-120 μm and suitable for separating spherical proteins within a molecular weight range of 5k-300k Da.

Cross-linked dextran G 75 serves as a gel filtration medium. It is a dextran-based matrix designed for gel filtration chromatography, featuring a particle size range of 40-120 μm. The separation range for globular proteins is 3K-80K Da, while it separates polysaccharides within the range of 1K-50K Da.

Cross-linked dextran G 50, medium, is composed of microspheres with an average particle size of D50=220-250 μm.

Cross-linked dextran G 50, fine, consists of microspheres with an average particle size (D50) of 110-130 μm.

Cross-linked dextran G 100, coarse, comprises microspheres with an average particle size of D50 of 190-210 μm.

Cross-linked dextran G 75, coarse is a microsphere with an average particle size D50 of 190-210 μm.

Cross-linked dextran G 25, coarse is a microsphere with an average particle size D50 of 200-250 μm.

Cross-linked dextran G 25, medium are microspheres with an average particle size D50 of 120-140 μm.

Cross-linked dextran G 25, fine is a microsphere with an average particle size D50 of 70-90 μm.

Cross-linked dextran G 15 is a hydrophilic gel used as a gel filtration medium (spherical protein separation range: >1500 Da; polysaccharide separation range: >1500 Da).

Cross-linked dextran G 10 is a weak cation exchanger and hydrophilic gel, suitable for use as a gel filtration medium (spherical proteins separation range: >700 Da; polysaccharides separation range: >700 Da).

Cross-linked sodium hyaluronate gel is a biomaterial formed through the cross-linking reaction of sodium hyaluronate. It possesses excellent moisturizing properties, viscoelasticity, and biocompatibility, making it suitable for arthritis treatment as well as for developing auxiliary materials in ophthalmic surgeries.

EDC hydrochloride (EDC-HCl Crosslinker) is a water-soluble carbodiimide compound. EDC hydrochloride, as a condensing agent, forms peptide bonds through the condensation reaction of carboxyl and amino groups and can be used to synthesize peptides with specific sequences and functions. EDC hydrochloride can covalently bind haptens to carrier proteins to form immune antigens, which are used in vaccine research. EDC hydrochloride can react with the 5 'phosphate group of nucleic acids and is used for the labeling of DNA and RNA. EDC hydrochloride can cross-link proteins with nucleic acids and is used to prepare immune cross-links. EDC hydrochloride, as a crosslinking agent, connects the amine-reactive NHS ester of biomolecules with the carboxyl group, which can be used for protein coupling to create hybrid molecules with new properties and functions.

DSSeb Crosslinker (Disuccinimidyl sebacate) is a dual N-hydroxyethyl ketone ester and cell-membrane-permeable amine-reactive crosslinker, suitable for protein crosslinking and investigating protein-protein interactions.

5-Bromocytosine can be used in the synthesis of cross-link products under anaerobic and aerobic conditions.

Alginate Methacryloyl (MW 50000) is a methacryloyl-modified alginate that shows promise for use as a scaffold in tissue engineering and as a 3D printing ink. It is characterized by its biocompatibility, non-immunogenicity, and low toxicity, and can physically cross-link with divalent cations (e.g., calcium). With the aid of a photoinitiator LAP, it assembles into fibrous hydrogels targeting bioactive adhesion sites, supporting tissue cells inherently and exhibiting biodegradability. Applications include cell culture, bio 3D printing, and tissue engineering.