cross-link

Cross-linked dextran G 200 is a hydrophilic gel designed for the separation of macromolecules based on molecular size exclusion. It operates through a gel permeation mechanism; its cross-linked structure forms a three-dimensional network with specific pore sizes, facilitating separation according to the hydrodynamic volume of molecules. This compound is utilized to regulate the partition coefficient of permeating solutes and maintain osmotic balance, and is commonly applied in gel filtration chromatography for the purification and analysis of biomacromolecules like proteins and nucleic acids. Additionally, Cross-linked dextran G 200 serves as a gel filtration medium (particle size range: 40-120 μm; spherical protein separation range: 5k-600k Da).

Cross-linked dextran G 150 is a hydrophilic gel used as a gel filtration medium, with a particle size range of 40-120 μm and suitable for separating spherical proteins within a molecular weight range of 5k-300k Da.

Cross-linked dextran G 75 serves as a gel filtration medium. It is a dextran-based matrix designed for gel filtration chromatography, featuring a particle size range of 40-120 μm. The separation range for globular proteins is 3K-80K Da, while it separates polysaccharides within the range of 1K-50K Da.

Cross-linked dextran G 50, medium, is composed of microspheres with an average particle size of D50=220-250 μm.

Cross-linked dextran G 50, fine, consists of microspheres with an average particle size (D50) of 110-130 μm.

Cross-linked dextran G 100, coarse, comprises microspheres with an average particle size of D50 of 190-210 μm.

Cross-linked dextran G 75, coarse is a microsphere with an average particle size D50 of 190-210 μm.

Cross-linked dextran G 25, coarse is a microsphere with an average particle size D50 of 200-250 μm.

Cross-linked dextran G 25, medium are microspheres with an average particle size D50 of 120-140 μm.

Cross-linked dextran G 25, fine is a microsphere with an average particle size D50 of 70-90 μm.

Cross-linked dextran G 15 is a hydrophilic gel used as a gel filtration medium (spherical protein separation range: >1500 Da; polysaccharide separation range: >1500 Da).

Cross-linked dextran G 10 is a weak cation exchanger and hydrophilic gel, suitable for use as a gel filtration medium (spherical proteins separation range: >700 Da; polysaccharides separation range: >700 Da).

Fructosyl-lysine is the precursor to glucosepane. Fructosyl-lysine is a lysine–arginine protein cross-link that can be an indicator in diabetes detection. Fructosyl-lysine is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction.

GMBS, a heterobifunctional cross-linker, possesses an N-hydroxysuccinimide (NHS) ester at one end and a maleimide group at the other. It is commonly used in bioconjugation to link amines and sulfhydryls [thiols], forming stable amide and thioether bonds, respectively, which are useful in creating protein and peptide conjugates.

Alagebrium is a advanced glycation endproducts (AGE) cross-link breaker.

DL-Glyceraldehyde (Glyceric aldehyde) is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels, DL-Glyceraldehyde can be a cytotoxin and a mutagen. A cytotoxin is a compound that kills cells. A mutagen is a compound that causes mutations in DNA. DL-Glyceraldehyde is a highly reactive compound that can modify and cross-link proteins. DL-Glyceraldehyde modified proteins appear to be cytotoxic, depress intracellular glutathione levels, and induce reactive oxygen species (ROS) production (PMID: 14981296 ). DL-Glyceraldehyde has been shown to cause chromosome damage to human cells in culture and is mutagenic in the Ames bacterial test.

CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent.

Fructosyl-lysine dihydrochloride (Fructoselysine), an Amadori glycation product, forms through the Maillard reaction between glucose and lysine. This compound serves as the precursor to glucosepane, a lysine–arginine protein cross-link, which is significant in the detection of diabetes [1].

5-Bromocytosine can be used in the synthesis of cross-link products under anaerobic and aerobic conditions.

PBD dimer-2 (compound 2c), a C8-linked pyrrolobenzodiazepine dimer, has the capability to span an extra base pair and cross-link the 5′-Pu-GA(T A)TC-Py sequence. It serves as a potential payload for antibody–agent conjugates (ADCs) and is under research for cancer treatments [1] [2].

Alginate Methacryloyl (MW 50000) is a methacryloyl-modified alginate that shows promise for use as a scaffold in tissue engineering and as a 3D printing ink. It is characterized by its biocompatibility, non-immunogenicity, and low toxicity, and can physically cross-link with divalent cations (e.g., calcium). With the aid of a photoinitiator LAP (HY-44076), it assembles into fibrous hydrogels targeting bioactive adhesion sites, supporting tissue cells inherently and exhibiting biodegradability. Applications include cell culture, bio 3D printing, and tissue engineering.