copper chelator

Neocuproine is a copper(I) chelator that enhances the purinergic component of vasoconstriction induced by electric field stimulation, and is often used as a ligand reagent and copper ion detector.Neocuproine forms stable complexes with copper ions and can play a catalytic role in certain chemical reactions and analytical methods.Neocuproine acts as a redox-active on the iron and cobalt ligand platform for protection against oxidative damage in NSC34 cells.

Tetraethylenepentamine Pentahydrochloride is a high affinity copper and zinc chelator.

EDTA copper(II) disodium salt is a metal chelator with antimicrobial, anti-inflammatory and antioxidant activity, slows down damage caused by metal ions, maintains osmotic pressure during protein purification, and can be used in the study of neurological disorders.

BLT-1 is a scavenger receptor BI (SR-BI)inhibitor.

Aβ-IN-10 (Compound Alz-5) is a bifunctional copper chelator and an inhibitor of beta-amyloid (Aβ), interacting with Aβ aggregates to reduce their neurotoxicity. This compound also displays antioxidative properties and exhibits moderate cytotoxicity in SH-SY5Y and HepG2 cells in the presence of CuCl2, with IC50 values of 65.5 and 31.2 μM, respectively. Additionally, Aβ-IN-10 reduces the increase in cell rigidity caused by Aβ.

ATN-224 is a second-generation analogue of ammonium tetrathiomolybdate, acting as a novel copper chelator. It demonstrates anti-angiogenic and anti-tumor properties by inhibiting CuZn superoxide dismutase 1 (SOD1).

MiADMSA (Monoisoamyl DMSA) is a lipophilic chelating agent that has shown potential as a chelator/detoxifier for arsenic and several heavy metals, including lead, mercury, cadmium, and gallium arsenide. It mitigates oxidative stress induced by sodium tungstate and improves liver and immune system alterations caused by chronic copper poisoning in Sprague Dawley rats. Additionally, MiADMSA protects human keratinocytes ['HaCaT'] from arsenic-induced oxidative stress.

Triethylenetetramine (Trientine) tetrahydrochloride is an orally active, potent, and selective copper chelator. It aids in the excretion of divalent copper ions from the body, reduces intestinal copper absorption, and minimizes copper accumulation. Additionally, Triethylenetetramine tetrahydrochloride exhibits potential anticancer properties through mechanisms such as telomerase inhibition, anti-angiogenesis, and promoting cancer cell apoptosis (apoptosis). This compound shows promise in the study of Wilson's disease, cancer, and diabetic complications.

Triplin is a chelator of copper ion. Triplin affects the transport of copper ions from ATX1 to RAN1.

CP21 is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio. It is active against P. falciparum when used at concentrations of 10 and 100 µM. CP21 inhibits production of prostaglandin I2 induced by epinephrine, arachidonic acid, or A23187 in isolated rat aortic rings with IC50 values of 1.3, 1.3, and 1.4 mM, respectively. It inhibits glutamate-induced oxytosis, as well as decreases iodoacetic acid-induced cytotoxicity in an in vitro model of ischemia, in HT22 mouse hippocampal cells (EC50s = 13 and 9.5 µM, respectively). CP21 (200 mg/kg) increases the excretion of iron, but not copper, zinc, calcium, or magnesium, in rabbits.

DOTA-ADIBO TFA is a DOTA-derived bifunctional chelating agent (BFC) that facilitates drug conjugation through a catalyst-free, copper-free click reaction. It enables the construction of fusion chelator systems, and after Cu[64] modification, it is used for the synthesis of radiotracers. It is applied in positron emission tomography (PET) imaging of tumors expressing integrin αvβ6.

DiAmSar is a metal chelator that has been linked to various tumor-targeting ligands and combined with the copper radioisotope [64Cu] for PET imaging in vivo.