copper

Copper probe CF4 (Copper fluor CF4) is a monovalent copper (Cu⁺)-specific fluorescent sensor based on a rhodol dye scaffold. TCF4 exhibits a 1:1 stoichiometric binding ratio and remains stable at pH 6–8, suitable for in vivo imaging.

Copper adarulatidum tetraxetanum (Copper adarulatide tetraxetan) is a diagnostic imaging agent.

Coppersensor-3 (CS3) is a bright small molecule fluorescent probe designed for the selective detection of Cu(I). It offers high selectivity and sensitivity, allowing for imaging of the labile copper pool at endogenous basal levels in living cells. Coppersensor-3 is applicable in studies of copper cell biology.

Coppersensor 1 (CS1) is a boron dipyrromethene-based fluorescent sensor for selective and sensitive detection of copper(I) ions (Cu + ) in biological samples. Coppersensor 1 can be imaged using any type of fluorescence microscope, including epifluorescence, confocal and multiphoton.

Ctrl-CF4-S2 is a control probe for the chemically modified Copper Fluor-4 (CF4), in which two of the four thioether ligands of the CF4 probe are replaced with methylene groups. Unlike CF4, which is a fluorescent probe used to detect the presence and distribution of copper ions, Ctrl-CF4-S2 does not respond to copper ions. This lack of response helps eliminate background signals from copper ions, thereby confirming whether the signals from CF4 accurately reflect the dynamic changes of copper ions within biological systems.

BP Fluor 546 Azide is a vibrant orange fluorescent dye that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC), resulting in the formation of stable triazole linkages.

Sulforhodamine-PEG4-DBCO is a PEG derivative comprising a DBCO group and a rhodamine dye. DBCO enables copper-free click chemistry, reacting with azide-containing compounds or biomolecules to form stable triazole linkages. This reagent is an ideal alternative for applications intolerant to copper, suitable for labeling cells, tissues, biomarkers, or nanoparticles.

BP Fluor 546 DBCO is an azide reaction probe suitable for imaging azide-labeled biomolecules using copper-free click chemistry.

Sulfo Cy7-N3 is a Sulfo Cy7-azide compound and functions as a fluorescent dye. It can be employed in cell imaging through click reactions. The molecule contains an azide group, enabling it to engage in a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules that have an alkyne group. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing DBCO or BCN groups.

Sulfo Cy5.5-N3 is a fluorescent dye known as a Sulfo Cy5.5 azide. This compound can be employed in cell imaging via click chemistry. It contains an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups. Additionally, it can engage in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules that have DBCO or BCN groups.

Cy5.5-N3, a Cy5.5-azide, is a fluorescent dye employed in cell imaging through click chemistry. It contains an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing alkyne groups. Additionally, it participates in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules possessing DBCO or BCN groups.

Alexa Fluor 594 azide is a bright red fluorescent azide-activated probe that reacts with terminal alkynes via copper-catalyzed click reactions (CuAAC) for single-molecule imaging.

Cyanine7 azide is a potent fluorescent dye employed for near-infrared in vivo imaging (λex=756 nm, λem=779 nm). It serves as a click chemistry reagent, featuring an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

IRDye 800CW, DBCO is a near-infrared (NIR) fluorescent dye equipped with a DBCO reactive group designed for conjugation. This DBCO group facilitates copper-free click chemistry by reacting with azide-tagged molecules or biomolecules.

Cy5-PEG-N3 (MW 10000) is a Cy5 azide fluorescent dye utilized for labeling amines in peptides, proteins, and oligonucleotides. As a click chemistry reagent, it features an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing alkyne groups. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that have DBCO or BCN groups.

Cy3-PEG-N3 (MW 3400) is a Cy3 azide fluorescent dye used for labeling amino groups in peptides, proteins, and oligonucleotides. As a click chemistry reagent, it features an azide group that can participate in a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) with alkyne-containing molecules. Additionally, it can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules possessing DBCO or BCN groups.

Cy5.5-PEG-N3 (MW 5000) is a fluorescent azide dye utilized for the amino group modification in peptides, proteins, and oligonucleotides. As a reagent for click chemistry, it incorporates an azide group that can engage in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Cy3-PEG-N3 (MW 2000) is a Cy3 azide fluorescent dye designed for labeling amino groups in peptides, proteins, and oligonucleotides. This compound acts as a click chemistry reagent, featuring an azide group that can partake in a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have DBCO or BCN groups.

Cy5-PEG-N3 (MW 3400) is a Cy5 azide fluorescent dye designed for use with amino groups in peptides, proteins, and oligonucleotides. Serving as a click chemistry reagent, it features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. Additionally, it undergoes strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules having DBCO or BCN groups.

Cy5.5-PEG-N3 (MW 3400) is a fluorescent dye azide used for labeling amino groups in peptides, proteins, and oligonucleotides. As a click chemistry reagent, it contains an azide group that participates in a copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. Additionally, it can engage in a strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that include DBCO or BCN groups.

Cy5.5-PEG-N3 (MW 2000) is a Cy5.5 azide fluorescent dye that targets amino groups in peptides, proteins, and oligonucleotides. As a click chemistry reagent, it features an azide group that undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. Additionally, it participates in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Cy3-PEG-N3 (MW 5000) is a fluorescent dye known as Cy3 azide, specifically designed for peptide, protein, and oligonucleotide amino groups. As a click chemistry reagent, it contains an azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing either DBCO or BCN groups.

Cy5.5-PEG-N3 (MW 10000) is a Cy5.5 azide fluorescent dye used for amino groups in peptides, proteins, and oligonucleotides. It serves as a click chemistry reagent, featuring an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Complex 3 is a fluorescent dithiocarbamate-copper complex exhibiting anticancer properties, specifically targeting mitochondria. It has excitation/emission maxima at 455-495/535 nm. Complex 3 inhibits the growth of pancreatic cancer cells BxPC-3, AsPC-1, PANC-1, and WI38, with IC50 values of 0.74, 0.41, 0.62, and 2.06 µM, respectively. In AsPC-1 cells, it induces lipid peroxidation, mitochondrial fragmentation and constriction, apoptosis, and cytokine-cytokine receptor interaction dysfunction. Furthermore, Complex 3 reduces tumor volume and induces apoptosis within tumors in AsPC-1 mouse xenograft models.