copolymers

N-(2-Hydroxypropyl)methacrylamide is utilized in the synthesis of copolymers for the targeted delivery of antileishmanial agents in [Visceral leishmaniasis].

m-PEG-OH (MW 1000) serves as a macromolecular initiator, facilitating the synthesis of amphiphilic block copolymers. These copolymers are utilized to create nanoscale micelles for delivering active drugs. When hydrophobic anti-cancer agent Paclitaxel (HY-B0015) is encapsulated within these micelles, it demonstrates enhanced activity against cancer cells compared to free Paclitaxel. Additionally, it predominantly accumulates in tumor tissues, with only limited distribution in healthy organs.

m-PEG-OH (MW 10000) serves as a macromolecular initiator in the synthesis of amphiphilic block copolymers, which can be used to create nanoscale micelles for delivering active drugs. These micelles encapsulate the hydrophobic anticancer agent Paclitaxel (HY-B0015) and exhibit greater efficacy in killing cancer cells compared to free Paclitaxel. Moreover, they preferentially accumulate in tumor tissues while having limited distribution in healthy organs.

Poly(ethylene glycol) dithiol (Mn 1500) is a thiol-modified PEG utilized for synthesizing dithiol-terminated amphiphilic diblock copolymers, which are applicable in drug delivery.

Mal-PEG-OH (MW 2000) serves as a macromolecular initiator for the ring-opening polymerization of LA to produce amphiphilic diblock copolymers. These amphiphilic block copolymers are used to prepare nanoparticles, forming an active drug delivery system. The nanoparticles can encapsulate Triptolide (HY-32735), addressing its poor water solubility and reducing its toxicity.

m-PEG-OH (MW 20000) can serve as a macromolecular initiator and participate in the synthesis of amphiphilic block copolymers. These copolymers can be used to prepare nanoscale micelles for delivering active drugs. The micelles encapsulate the hydrophobic anticancer agent Paclitaxel (HY-B0015), enhancing its ability to kill cancer cells compared to free Paclitaxel. Additionally, the micelles preferentially accumulate in tumor tissues while showing limited distribution in healthy organs.