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(1)
By Target- Autophagy
- Mitochondrial Metabolism(1)
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Results for "
cisd1
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Recombinant Protein1
- Antibody Products1
SB-T-101141
T211012186348-05-0
SB-T-101141 is a novel taxane drug effective in inducing atypical ferroptosis, thereby overcoming resistance of breast cancer to Paclitaxel. It promotes the generation of iron ions, ferrous ions, and reactive oxygen species (ROS). SB-T-101141 stably binds to KHSRP, inhibiting the expression of the iron-dependent CISD1 related to iron homeostasis. It synergistically enhances the activation of the iron-dependent JNK and PERK pathways through KHSRP. SB-T-101141 inhibits breast tumor growth in MCF-7(PR)/MDA-MB-231(PR) or KHSRP knockout MCF-7 xenograft mouse models.
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