ceramide-mediated

ARN14974 is a benzoxazolone carboxamide. ARN14974 is a potent inhibitor of acid ceramidase with IC50 of 79 nM[1].

LCL768 is a ceramide analogue that attenuates PARKIN succinylation, thereby promoting PARKIN activation and mitophagy. It induces the accumulation of CerS1-mediated endogenous C18-ceramide in mitochondria, facilitating mitophagy through DRP1 activation via C644 site nitrosylation. Additionally, LCL768 alters mitochondrial metabolism, depleting fumarate and inhibiting tumor growth. Furthermore, it ameliorates sensorimotor deficits in neurodegenerative diseases such as ALS.

Palmitoyl serinol (N-Palmitoyl serinol), an analog of the endogenous cannabinoid N-palmitoylethanolamine, significantly stimulated an IL-4-mediated decrease in cellular ceramide levels in human epidermal keratinocytes (KC). Palmitoyl serinol stimulates the production of specific ceramide species and neurotransmitters through an endogenous cannabinoid receptor CB1-dependent mechanism. production of specific ceramide species as well as the total amount of ceramide.

C2 Dihydro Ceramide (d18:0/2:0) (C2 Dihydroceramide) is a short-chain ceramide that is a precursor of ceramide synthesis and stimulates ABCA1-mediated cholesterol efflux.