cellular amyloid-β

Lupanine ((+)-Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid β-oligomers (SO-Aβ) toxicity in cellular models in association with the anti-apoptotic PI3K Akt Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes.

Lupanine hydrochloride, a natural ketonic derivative of Sparteine ((+)-Sparteine), exhibits ganglioplegic activity and binds to the nicotinic receptor (nAChR) with a K i value of 500 nM [1].

Lupanine perchlorate is a bioactive chemical.

Lupanine dihydrochloride, (+/-)- is a bioactive chemical.