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(5)
By Target- CDK
- Apoptosis(2)
- Autophagy(1)
- Chk(1)
- ERK(1)
- FLT(1)
- GSK-3(1)
- PDGFR(1)
- Src(1)
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Results for "
cdc2/cyclinb
" in TargetMol Product Catalog- Inhibitors & Agonists6
- Natural Products1
Olomoucine
T21588101622-51-9In house
Olomoucine is an ATP-competitive inhibitor of Cdk2 cyclin A, Cdc2 CyclinB, CDK2 CyclinE, CDK5 p35, and ERK1 p44 MAP kinase with IC50s of 7, 7, 7, 3, and 25 µM, respectively. It regulates the cell cycle and exhibits anti-melanin tumor activities.
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Seliciclib
Cited
R-roscovitine, Roscovitine, CYC202
T2095186692-46-6
Seliciclib (Roscovitine) is a potent inhibitor of Cdk2 cyclin E (IC50=0.1 µM). Seliciclib also inhibits Cdk7 cyclin H, Cdk5 p35 and Cdc2 cyclin B (IC50=0.49 0.16 0.65 µM). Seliciclib has antitumor activity.
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CitedPurvalanol A
NG-60
T2059212844-53-6
Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70 4 35 850 nM for cdk2-cyclin A B E, and cdk4-cyclin D1, respectively.
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ng 52
NG-52, NG52, Compound 52
T2028212779-48-1
NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.
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Butyrolactone I Cited
Olomoucin
T2519287414-49-1
Butyrolactone I (Olomoucin) is an ATP-competitive inhibitor of CDK and cdc2 kinase family. Butyrolactone I shows antitumor effects in non-small cell lung, small cell lung, and prostate cancer cell lines.
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CitedCHIR-124
CHIR124, CHIR 124
T6350405168-58-3
CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2 4.
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