cardiac action potential duration

1. Oxypeucedanin ((+-)-Oxypeucedanin) has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeucedanin is a kind of open-channel blocker of the hKv1.5 channel and it prolongs the APD; therefore, it is an excellent candidate as an antiarrhythmic drug for atrial fibrillation.

Cerberin is a cardiac glycoside found in C. odollam with cytotoxic and cardiac regulatory properties. It exhibits cytotoxicity against KB and NCI H187 cancer cells (IC50s = 1.92 and 1.24 μg/mL). Cerberin inhibits Na+/K+-ATPase, elevating intracellular sodium levels and prolonging action potential duration in cardiac cells.