carboxylic acid

JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)

CPI-0610 carboxylic acid is an effective and selective small molecule inhibitor of bromine domain and outer end (BET) protein as a ligand of PROTAC target protein. CPI-0610 carboxylic acid may have anticancer and anticancer activities.

I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).

(4R,5S)-Nutlin Carboxylic Acid (MDM2 Ligand 2), a Nutlin 3-based MDM2 ligand, can be conjugated to a protein-binding ligand via a linker to create PROTACs[1].

Nutlin Carboxylic Acid (MDM2 ligand 1), derived from Nutlin 3, serves as an MDM2 ligand. It can be attached to a protein ligand via a linker to create PROTACs[1].

JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a BRD4 ligand and a PROTAC linker, and is used in the synthesis of PROTAC BRD4 Degrader-29.

Fmoc-azetidine-3-carboxylic acid is a valuable compound for life sciences research (catalog number: T65634, CAS number: 193693-64-0).

Azetidine-3-carboxylic acid, catalog number T66328 and CAS number 36476-78-5, is a valuable organic compound utilized in life sciences research.

(R)-Azetidine-2-carboxylic acid, with catalog number T66331 and CAS number 7729-30-8, is a valuable organic compound for life sciences research.

1-Cbz-azetidine-3-carboxylic acid (catalog number: T66609, CAS number: 97628-92-7) is a valuable organic compound for life sciences research.

1-Boc-azetidine-3-carboxylic acid is a valuable organic compound for life sciences research (catalog number T67359, CAS number 142253-55-2).

Biotin-PEG3-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This heterobiofunctional biotin PEG derivative contains a carboxylic acid group. The hydrophilic PEG spacer arm imparts water solubility to the biotinylated molecule. [PEG Linkers] may be useful in the development of antibody-drug conjugates and drug delivery methods.

N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used for synthesizing PROTACs, consisting of an amino group and two terminal carboxylic acids[1].

N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEGylated PROTAC linker with azide, fluorescein, and carboxylic acid functional groups.

Amino-PEG36-CONH-PEG36-acid is a polyethylene glycol (PEG)-based linker featuring amino and carboxylic acid functionalities, utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

DBCO-NHS ester 3 (Compound 12) is a cleavable linker utilized in the synthesis of antibody-drug conjugate (ADC). It is a derivative of Dibenzylcyclooctyne (DBCO) resulting from the activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].

CCW16-C9-BocNH is composed of an RING finger protein 4 (RNF4)-recruiting ligand, includes a linker with both hydrophobic and hydrophilic elements, and features a pendant amine that reacts with a carboxylic acid on the target ligand. It is crucial for synthesizing protein degraders used in targeted protein degradation and PROTAC research.

Pomalidomide-benzyl-piperazine hydrochloride functions as a building block for creating targeted protein degraders and PROTACs. It contains a Cereblon (CRBN)-binding ligand, a stable linker, and a pendant amine that can react with a carboxylic acid on the target ligand.

Pomalidomide-pyridine-PEG1-piperazine hydrochloride is a key building block in the synthesis of targeted protein degraders and PROTACs. It features a Cereblon (CRBN)-recruiting ligand, a more rigid linker, and a pendant amine designed to react with a carboxylic acid on the target ligand.

Pomalidomide-methylamino-PEG1-NH2 hydrochloride, acts as a building block for developing protein degraders and in PROTAC research. It comprises a Cereblon (CRBN)-recruiting ligand, a linker, and a pendant amine that facilitates reactivity with a carboxylic acid on the target ligand.

(S,R,S)-VL285 Phenol-PEG4-NH2 HCl is a key component in the synthesis of molecules used in PROTAC research and targeted protein degradation. It features a (VHL)-recruiting ligand with a unique exit vector from VH032 (901490), a PEG linker, and a pendant amine for reacting with the carboxylic acid on the target ligand.

DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]

SJ44236 is a BET PROTAC degrader capable of degrading BRD2 (DC50 = 0.127 nM), BRD3, and BRD4. It shows cytotoxicity in MV4-11 and HD-MB03 cells with IC50 values of 0.12 nM and 0.92 nM, respectively. The compound downregulates c-Myc expression and upregulates p53 expression. In mice, SJ44236 demonstrates good oral bioavailability (45%). [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonE3ligaseLigand 54]

Hydroxy-PEG3-acid is a PEG derivative containing a hydroxyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functi