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By Target- PI3K
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Results for "
cal-130
" in TargetMol Product Catalog- Inhibitors & Agonists4
- Peptide Products1
CAL-130 Hydrochloride
T10660L1431697-78-7
CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
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CAL-130 Racemate
T10660L2474012-90-3
CAL-130 Racemate, the racemate of CAL-130, is a PI3Kδ and PI3Kγ inhibitor with IC50s of 1.3 and 6.1 nM, respectively.
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PGD97
TP30182717490-36-1
PGD97 is a selective cyclic peptide inhibitor targeting the CAL CFTR interaction, with its desulfurization-cyclized form exhibiting a KD value of 6 nM for the CAL PDZ domain. It shows a selectivity of at least 130-fold over the NHERF1 2 PDZ domains. PGD97 stabilizes F508del-CFTR on the cell membrane, enhancing CFTR function necessary for normal pulmonary fluid balance. This compound is applicable in cystic fibrosis research.
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