ca1

Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a phosphodiester (PDE) inhibitor. Bucladesine sodium has anti-inflammatory activity.

Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.

MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle with an increase in insulin sensitivity.

BRCA1-IN-1 is a novel small-molecule-like inhibitor of BRCA1 with an IC50 of 0.53 μM and a Ki of 0.71 μM.

BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.

ABCA1 inducer 1, a non-lipid inducer of ABCA1, enhances ABCA1 expression in E3/4FAD mice expressing human APOE 3/4, augments the lipidation of apolipoprotein (APOE), and reverses various Alzheimer's disease (AD) phenotypes without increasing triglycerides.

ABCA1 inducer 2 is a non-lipogenic inducer of ABCA1. It increases the expression of ABCA1 by targeting the LXR pathway, thereby reducing lipid accumulation induced by ox-LDL and inhibiting foam cell formation. ABCA1 inducer 2 holds potential as an anti-atherosclerotic agent.

As-CA11 is a thioredoxin reductase (TrxR) inhibitor with an IC50 value of 18.7 nM. It exhibits potent inhibitory activity against HeLa, HepG2, A549, and HL-60 cells, with IC50 values of 0.35, 0.3, 0.43, and 0.28 μM, respectively. As-CA11 induces apoptosis and reactive oxygen species (ROS) production in cancer cells, decreases reduced thioredoxin (Trx) levels, and increases oxidized thioredoxin (Trx) levels. Additionally, As-CA11 demonstrates antitumor activity in a 4T1 tumor-bearing mouse model.

CA12 modulator-1 acts as a regulator of carbonic anhydrase 12 (CA12).

TCA1 (TCA 1) is a small molecule with activity against drug-resistant and persistent tuberculosis.

KCa1.1 Channel Activator-1, a hybrid derivative of Quercetin, selectively stimulates the vascular KCa1.1 channels while also blocking CaV1.2 channels. Additionally, it demonstrates weak myorelaxant activity.

KCa1.1 channel activator-2, a hybrid derivative of Quercetin, selectively stimulates the vascular KCa1.1 channels. This compound demonstrates significant myorelaxant activity.

The Anti-BRCA1 Antibody (BR64) is a mouse IgG1, κ chimeric antibody that specifically targets human BRCA1. The recommended isotype control for the Anti-BRCA1 Antibody (BR64) is the Mouse IgG1 kappa, Isotype Control.

Anti-CA19-9 Antibody (1116-NS-19-9) is a mouse IgG1, κ chimeric antibody designed to target human CA19-9. The recommended isotype control for this antibody is Mouse IgG1 kappa, Isotype Control.

CA1001 is a humanized anti-GPIbα Fab Antibody, which has potent anti-thrombotic effects

Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).

Eldacimibe (WAY-ACA-147) is an ACAT2 inhibitor for the treatment of cardiovascular disease and endocrine and metabolic disorders, study of atherosclerosis and hypercholesterolemia.

GAL-021 an intravenous BKCa-channel blocker.

Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.

Adenosine (D-Adenosine) is a natural product, a ribonucleoside consisting of adenine bound to ribose. Adenosine has vasodilatory, antiarrhythmic and analgesic effects.

Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor. Carboplatin binds to DNA, inhibits replication and transcription, and induces cell death. Carboplatin has antitumor activity.

Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, exhibiting antinociceptive, anti-inflammatory, and antioxidant activities in different research models.

Rucaparib (PF-01367338) is a PARP protein inhibitor (PARP-1 Ki=1.4 nM) and hexose hexose-6-phosphate dehydrogenase (H6PD) inhibitor with oral activity. Rucaparib exhibits antitumor activity, with activity against desmoplasia-resistant prostate cancer (CRPC).

(E)-β-Farnesene (trans-β-Farnesene) is a sesquiterpene hydrocarbon found in Phlomis aurea Decne, serving as the primary component of many aphid alarm pheromones that disrupt feeding. It also impairs the development and survival of Chilo suppressalis larvae by disrupting their hormone balance.