c-kitd816v

Amuvatinib hydrochloride (MP470 hydrochloride) is an orally administered multi-targeted tyrosine kinase inhibitor effective against mutant forms of c-Kit, PDGFRα, Flt3, c-Met, and c-Ret, and it suppresses DNA repair by inhibiting the RAD51 protein, contributing to its antineoplastic activity[1][2][3][4].

9-Methoxyellipticine is a natural alkaloid and potent c-Kit kinase inhibitor exhibiting cytotoxic properties. It inhibits c-kit(wt) and c-Kit(D816V) with IC₅₀ values of 0.8 and 0.6 µM respectively, making it suitable for leukaemia research.