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Results for "
c-kitd816v
" in TargetMol Product Catalog- Inhibitors & Agonists2
Amuvatinib hydrochloride
MP470 hydrochloride, HPK 56 hydrochloride
T142821055986-67-8
Amuvatinib hydrochloride (MP470 hydrochloride) is an orally administered multi-targeted tyrosine kinase inhibitor effective against mutant forms of c-Kit, PDGFRα, Flt3, c-Met, and c-Ret, and it suppresses DNA repair by inhibiting the RAD51 protein, contributing to its antineoplastic activity[1][2][3][4].
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9-Methoxyellipticine
T3669910371-86-5
9-Methoxyellipticine is an alkaloid and a derivative of the DNA intercalating agent ellipticine that has been found in O. maculataand has anticancer activity.It intercalates into DNA and is an inhibitor of wild-type c-Kit and c-Kit containing the D816V activating mutation (c-KitD816V; IC50s = 0.8 and 0.6 μM, respectively).
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