bufalin

Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic a

Bufalin (compound 2a) is a microbial transformation product of the bufadienolide [1].

Bufalin (Standard) is a reference standard for research and analysis in studies involving Bufalin. Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.

3-Oxo-bufalin is an active compound isolated from cultured toad liver tissues. It is produced via metabolic pathways as a stereoselectively distinct metabolite of Bufalin, catalyzed by the enzyme 3β-dehydrogenase. Bufalin acts as an inhibitor of Na+/K+-ATPase and possesses antitumor activity.

19-Hydroxybufalin is a natural product, inhibits epithelial-mesenchymal transition and attenuates the migration and invasion of PC3 cells.

7beta-Hydroxybufalin is a natural product

1beta-Hydroxybufalin is a natural product from animals

3-Epicinobufagin (compound IX) serves as a metabolic marker for Bufalin, indicating metabolic status through the detection of its levels in serum and urine.