bpk

BPK-29 hydrochloride is a specific ligand that disrupts atypical orphan nuclear receptor NR0B1-protein interactions by covalently modifying C274, impairing the anchorage-independent growth of [KEAP1-mutant cancer cells].

BPK-29, a ligand specifically targeting the atypical orphan nuclear receptor NR0B1, disrupts its protein interactions through covalent modification at C274, thereby impairing the anchorage-independent growth of KEAP1-mutant cancer cells.

BPK-21 is an active acrylamide compound that effectively suppresses T cell activation by blocking the function of ERCC3, a helicase enzyme. BPK-21 specifically targets C342 within the ERCC3 helicase.

BPK-25 is an active acrylamide. It can inhibit the activation of TMEM173 by the cyclic dinucleotide ligand cGAMP, suppress the activation of NF-κB, promote nucleosome remodeling, and lead to the degradation of the deacetylated (NuRD) complex proteins.

BPKDi is a potent and selective inhibitor of PKD (protein kinase D).