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Cat No. | Product Name | Synonyms | Targets |
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T1973 | PFI-4 | PFI4 | Epigenetic Reader Domain |
PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor. | |||
T1850 | Balicatib | AAE581 | Cysteine Protease |
Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis. | |||
T22702 | CYM 50769 | Neuropeptide W | |
CYM 50769 is a neuropeptide W/B receptor 1 (NPBWR1, GPR7) antagonist(IC50 = 0.12 μM). CYM 50769 inhibited NPW activation of NPBWR1 with a submicromolar IC50, and displayed high selectivity against a broad array of off-ta... | |||
T7469 | Alendronic Acid | alendronate | Others |
Alendronic Acid (alendronate) is a nonhormonal medication used for osteoporosis, osteogenesis imperfecta, and several other bone diseases. | |||
T8550 | NDMC101 | Others , NF-κB , Proteasome | |
NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity. | |||
T38776 | LP-922056 | Wnt/beta-catenin | |
LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively. | |||
T39508 | KY-02327 | Others | |
KY-02327, a metabolically stabilized analog of KY-02061, serves as a potent inhibitor of the Dishevelled (Dvl)-CXXC5 interaction. This compound activates the Wnt/β-catenin pathway, thereby promoting osteoblast differenti... | |||
T2121 | SW033291 | Dehydrogenase | |
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues. | |||
T21616 | L-006235 | L 006235 | Cysteine Protease |
L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM. | |||
T1867 | Otenaproxesul | ATB 346 | Apoptosis , COX |
Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity. | |||
T8645 | PF-06446846 | Others | |
PF 06446846 is a potent and selective PCSK9 inhibitor | |||
T16159 | Muramyl dipeptide | MDP | NOD |
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation... | |||
T2334 | Avanafil | TA1790 | PDE |
Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction. | |||
T6574 | Lumiracoxib | Prexige,COX-189 | COX |
Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4. | |||
T13324 | VUF11207 fumarate | CXCR , Arrestin | |
VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1). | |||
T23383 | SR11237 | SR 11237 | Others , RAR/RXR |
SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element. | |||
T1817 | GNF-2 | GNF2 | SARS-CoV , Bcr-Abl |
GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl. | |||
T23146 | PHA 568487 free base | PHA 568487 | AChR |
The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia... | |||
T6451 | Clodronic acid disodium salt | Loron,Clodronate Disodium,Lodronate | Others |
Clodronic acid disodium salt (Lodronate), a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption. | |||
T1944 | LDN-214117 | ALK , TGF-beta/Smad | |
LDN-214117 is a potent and selective ALK2 inhibitor. | |||
T21460 | Teriparatide acetate | hPTH 1-34 (acetate salt),Parathar acetate,Forteo | Others |
Teriparatide acetate (Forteo) is a PHT agonist, with an IC50 of 2 nM in HEK293 cells.Teriparatide acetate is a recombinant form of parathyroid hormone. It is an effective anabolic (i.e., bone growing) agent used to treat... | |||
T6374 | Alfacalcidol | Bondiol,Etalpha,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol | Others |
Alfacalcidol (Etalpha) (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication. | |||
T15259 | Evatanepag | CP-533536 free acid | Prostaglandin Receptor |
Evatanepag (CP-533536 free acid) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability to heal fractures when administered l... | |||
T7566 | GRGDSPK | EMD 56574 | Others |
GRGDSPK (EMD 56574) is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules. | |||
T1925 | PLX647 | c-Fms , c-Kit | |
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM). | |||
T9026 | MEISi-2 | Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide | Others |
MEISi-2 is a potent MEIS inhibitor (MEISi). MEISi-2 significantly inhibits MEIS-luciferase reporters in vitro. | |||
T29978 | Amicibone | Amicibono | |
Amicibone is a biochemical. | |||
T8400 | Pamidronic acid | Wnt/beta-catenin | |
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells | |||
T0308 | Etidronic acid | HEDPA,Etidronate,HEDP | Apoptosis , Phosphatase , Others , HBV |
Etidronic acid (HEDP) is a diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover. | |||
T13911 | Tacalcitol monohydrate | Curatoderm monohydrate,TV 02 monohydrate,TV-02H monohydrate,1,24(R)-Dihydroxyvitamin D3 monohydrate | Cysteine Protease |
Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis. | |||
T0575 | 1-Methylimidazole | Others | |
1-Methylimidazole is a metabolite of 1-methyl-2-thioimidazole (methimazole) which inhibits bone resorption. | |||
T0379 | Risedronic Acid | Risedronate | Others , Transferase |
Risedronic Acid (Risedronate), a pyridinyl biphosphonate, can inhibit osteoclast-mediated bone resorption. | |||
T9603 | MNITMT | ||
MNITMT is a potent immunosuppressive agent without bone marrow toxicity [1]. | |||
T77581 | KM02894 | GluR | |
KM02894 is a glutamate release inhibitor. Cancer cells release high levels of glutamate that can disrupt normal bone turnover, which can lead to cancer-induced bone pain.KM02894 may be used in the study of tumor-related ... | |||
T1641 | Strontium ranelate | Distrontium renelate,S12911 | Calcium Channel , CaSR |
Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both in... | |||
T19415 | Medronic acid | Methylenediphosphonic acid | Others |
Medronic acid (Methylenediphosphonic acid), a methylene-substituted bisphosphonate, exhibits affinity for and adherence to hydroxyapatite crystals within the bone matrix. Accumulating at sites of osteoid mineralization, ... | |||
T25492 | Hepln-13 | Hepln 13,Hepln13 | c-Met/HGFR |
Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis. | |||
T0309 | Ipriflavone | Osteofix | advanced glycation end products |
Ipriflavone (Osteofix) (Osteofix) is a feed additive and a catabolic agent. It is used to inhibit bone resorption. | |||
T8489 | Minodronic acid monohydrate | Transferase | |
Minodronic acid monohydrate is an farnesyl diphosphate synthase inhibitor that acts as a bone resorption inhibitor. | |||
T6373 | Alendronate sodium hydrate | G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,G-704650 Adronat,Fosamax | Transferase |
Alendronate sodium hydrate (MK 217) is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis. | |||
T39024 | PrNMI | Cannabinoid Receptor | |
PrNMI is a highly effective and orally active agonist targeting the peripherally restricted cannabinoid 1 receptor (CB1R). It exhibits pronounced analgesic properties, efficiently suppressing both chemotherapy-induced pe... | |||
T7809L | Ipamorelin 2 Pivalic acid | NNC-26-0161 | Others |
Ipamorelin 2 Pivalic acid (NNC-26-0161) is a growth-hormone-releasing peptide, induces longitudinal bone growth in rats. | |||
T4662 | SJ000291942 | TGF-beta/Smad | |
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. | |||
T2188 | Thonzonium Bromide | Proton pump , Antibacterial , Autophagy | |
Thonzonium bromide is a mono-cationic surfactant that is structurally similar to Farnesol as an antimicrobial agent. It inhibits proton transport in a dose-dependent manner (EC50=69 μM). It inhibits RANKL-induced osteocl... | |||
T20112 | Triphenyl bismuth | NSC 465,NSC-465,NSC465 | Others |
Triphenyl bismuth (NSC-465) is an additive for making biomedical resins visible on x-ray images and can be used as a radiopaque agent for orthopaedic bone cements. | |||
T7566L1 | GRGDSPK acetate | GRGDSPK acetate(111119-28-9 Free base) | Beta Amyloid |
GRGDSPK acetate shows inhibitory activity against integrin-fibronectin binding and can be used in research on integrins in bone formation and resorption. | |||
T6112 | Doxercalciferol | TSA 840,Hectorol,1.alpha.-Hydroxyvitamin D2,1α-hydroxyvitamin D2 | Others |
Doxercalciferol (TSA 840) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease. | |||
T21299 | Zoledronic acid monohydrate | zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate | Apoptosis , Others , Autophagy |
Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity. | |||
T1041 | Risedronate Sodium | NE 58095 Sodium,Risedronic Acid Sodium | HBV , Transferase |
Risedronate Sodium (NE 58095 Sodium) is an aminobisphosphonate derivative of etidronic acid and CALCIUM CHANNEL BLOCKER that inhibits BONE RESORPTION and is used for the treatment of OSTEOPOROSIS. | |||
T16859 | SBI-425 | Others | |
SBI-425 is an effective and orally bioavailable inhibitor of tissue-nonspecific alkaline phosphatase (TNAP). SBI-425 effectively inhibits TNAP in the vasculature and improves cardiovascular parameters and survival withou... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5751 | Tigogenin | Others | |
Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis. | |||
T5S2129 | Sciadopitysin | TNF , NF-κB | |
Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in o... | |||
T5575 | Cycloastragenol | Cyclogalegenol,Astramembrangenin | Epigenetic Reader Domain , Telomerase |
Astramembrangenin (Cycloastragenol (Astramembrangenin)) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therape... | |||
TN1494 | Cimicifugoside H-1 | Others | |
Cimicifugoside H1 shows the protective function to cerebral neuron during cerebral ischemia. | |||
T4S0969 | Obtusifolin | Antioxidant , NF-κB | |
1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be... | |||
T2988 | (-)-Epigallocatechin Gallate | Epigallocatechol Gallate,EGCG | Ferroptosis , Reactive Oxygen Species , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite , Autophagy |
(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptor... | |||
T2902 | Costunolide | Costus lactone,NSC 106404,Costunolid,(+)-Costunolide | Apoptosis , Endogenous Metabolite , Telomerase |
Costunolide (Costus lactone) has anti-inflammatory and anti-oxidant properties and mediates apoptosis. | |||
TN7036 | N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide | (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14 | Wnt/beta-catenin |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-catenin signaling pa... | |||
T5712 | Zerumbone | Antioxidant , HSV | |
Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory a... | |||
T24744 | Rubone | ||
Rubone is the tumor suppressor miRNA-34a modulator that acts by inhibiting the growth of hepatocellular carcinoma. | |||
T0912 | Tetracycline hydrochloride | NCI-c55561,Tetracycline HCl | ribosome , Antibacterial , Antibiotic |
Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium ... | |||
T13768 | (+)-Medicarpin | Estrogen/progestogen Receptor | |
(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from multiple medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium flo... | |||
T3488 | Tectorigenin | 4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine | Apoptosis |
Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Re... | |||
TN1117 | Veraguensin | p38 MAPK , NF-κB , Antibiotic , Parasite , Antifection | |
Veraguensin is derived from Magnolia sp.. Veraguensin inhibits bone resorption and shows high antileishmanial activity. | |||
T2820 | Glycitin | Glycitein-7-β-O-glucoside,Glycitein 7-O-β-glucoside | Others , Influenza Virus , Antibacterial |
Glycitin (Glycitein 7-O-β-glucoside), a natural isoflavone isolated from legumes, can promote the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover. | |||
TJS0856 | Dalbergin | 6-Hydroxy-7-Methoxy-4-Phenylcoumarin | Others |
1. Dalbergin (6-Hydroxy-7-Methoxy-4-Phenylcoumarin) exhibits similar bone conserving effect against bone-loss as estradiol treatment, it as a therapeutic candidate against postmenopausal osteoporosis. 2. Dalbergin preven... | |||
T3S2312 | Poncirin | Isosakuranetin-7-neohesperidoside | Apoptosis , Others |
1. Poncirin (Isosakuranetin-7-neohesperidoside) shows a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-791, in a dose-dependent manner. 2. Poncirin prevents adipogenesis, enha... | |||
T3004 | Batilol | Batilolum,Stearyl monoglyceride,Batyl alcohol,1-O-Octadecylglycerol | Others , Endogenous Metabolite |
Batilol (Stearyl monoglyceride), isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent. | |||
T8103 | H-HoArg-OH | Endogenous Metabolite , Phosphorylase | |
H-HoArg-OH, a homologue arginine, is a strong inhibitor of human liver and bone alkaline phosphatase. | |||
T3808 | Icariside I | Lcariside I,Icariin I,Icarisid I | Others |
Icariside I (Lcariside I) is isolated from Epimedium herb. It can stimulate osteogenic differentiation of BMSCs and inhibit bone resorption activity of osteoclasts. | |||
T9171 | Methenolone enanthate | Others | |
Methenolone enanthate is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure. | |||
T7437 | 3-(3-Hydroxyphenyl)propionic Acid | m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid | Others , Endogenous Metabolite |
3-(3-Hydroxyphenyl)propionic Acid (m-Hydroxyphenylpropionic acid) is one of the major metabolites of ingested caffeic acid.it inhibited osteoclastogenesis and bone osteoclastic resorptive activity. | |||
T8117 | Metenolone acetate | Methenolone acetate | Others , Androgen Receptor |
Metenolone acetate (Methenolone acetate) is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure. | |||
T2980 | Chondroitin sulfate | Chonsurid,Chondroitin polysulfate | MMP , Others , Endogenous Metabolite , NO Synthase |
Chondroitin sulfate (Chonsurid) is extracted from shark bone;Store the product in sealed, cool and dry condition | |||
T2845 | Imperatorin | Ammidin,8-Isoamylenoxypsoralen,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen | TRP/TRPV Channel , AChR , AChE , NOD |
Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo. | |||
T6S1966 | Curculigoside | Curculigoside A | Antioxidant , NF-κB , JAK , STAT |
1. Curculigoside (Curculigoside A) can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disord... | |||
TN3209 | 3′,4′,7-Trihydroxyflavone | ATPase , Others , p38 MAPK , NF-κB | |
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclasto... | |||
T5S0662 | Gelsemine | Gelsemin | Antioxidant |
1. Gelsemine (Gelsemin) has antitumor activity. 2. Gelsemine has anti-oxidative activity. 3. Gelsemine has anti-hyperlipidemic activity. 4. Gelsemine has marked antinociception in inflammatory, neuropathic and bone cance... | |||
T3S0137 | Bavachalcone | Antibacterial , Antibiotic | |
Bavachalcone is a major bioactive compounds isolated from Psoralea corylifolia L. it may be useful as a therapeutic drug for bone resorption-associated diseases.Bavachalcone can protect the endothelial function by increa... | |||
T3924 | Astragaloside II | Astrasieversianin VIII | TGF-beta/Smad |
Astragaloside II (Astrasieversianin VIII) is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteogenic activities, differentiation, ... | |||
T3777 | Praeruptorin A | (+)-Praeruptorin A | CaMK , NF-κB |
Praeruptorin A ((+)-Praeruptorin A) has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or... | |||
TN1711 | Gossypetin | Antioxidant , p38 MAPK , MAPK , Antibacterial | |
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosc... | |||
T3S1729 | Dihydrolycorine | Others | |
1. Dihydrolycorine-HCL(DL) shows hypotensive effects, it can block alpha 1-adrenoceptors. 2. Dihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inh... | |||
T3804 | Neomangiferin | Mangiferin 7-glucoside | Phosphatase |
Neomangiferin (Mangiferin 7-glucoside) has beneficial effects on high fat diet-induced nonalcoholic fatty liver disease in rats. Neomangiferin and mangiferin inhibit tartrate-resistant acid phosphatase, a biochemical mar... | |||
T5770 | Alisol B | RANKL/RANK | |
Alisol B may be a potential novel therapeutic molecule for bone disorders through targeting the differentiation of osteoclasts as well as their functions. Alisol B also inhibited RANKL-induced expression of NFATc1 and c-... | |||
T3662 | Eleutheroside E | NF-κB | |
Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus formation, cartilage damage, bone erosion of CIA mice, the ... | |||
T6316 | Calcitriol | Topitriol,Rocaltrol,Calcijex,RO215535,1,25-Dihydroxyvitamin D3 | Endogenous Metabolite |
Calcitriol (1,25-Dihydroxyvitamin D3) is a metabolite of vitamin D and a vitamin D receptor (VDR) agonist (IC50=0.4 nM). Calcitriol increases intestinal absorption of calcium and phosphorus, and increases bone resorption... | |||
TN1918 | Medicarpin | Apoptosis , BCL , ROS , JNK | |
Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of peak bone mass, and is devoid of uterine estrogenicity; in add... | |||
T8194L | Soy Isoflavone | Others | |
Soy Isoflavone is extracted from the seeds of leguminous plants. The isoflavones in soybeans are natural phytoestrogens, which have good medicinal value and can reduce the incidence of breast cancer in women, relieve men... | |||
T4237 | Rubiadin-1-methyl ether | Rubiadin 1-methyl ether | Anti-infection , NF-κB |
Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nu... | |||
T5544 | 2-Furoic acid | Furan-2-carboxylic acid | Anti-infection , ATP Citrate Lyase , Endogenous Metabolite , Acyltransferase |
2-Furoic acid (Furan-2-carboxylic acid), an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosi... | |||
T3674 | Hydroxysafflor yellow A | HSYA,Safflomin A | TGF-beta/Smad |
Hydroxysafflor yellow A (Safflomin A) inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacit... | |||
T2698 | Asperosaponin VI | Akebia saponin D,Asperosaponin Ⅵ | Apoptosis , Others , Caspase |
Asperosaponin VI (Akebia saponin D) , the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures. | |||
TN1215 | (2S)-2'-Methoxykurarinone | 2'-Methoxykurarinone,2'-O-Methylkurarinone | Akt , Antifection |
(2S)-2'-Methoxykurarinone is isolated from the roots of Sophora flavescens. (2S)-2'-Methoxykurarinone has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone inhibits osteo... | |||
T2818 | Methyl Vanillate | Reactive Oxygen Species , Wnt/beta-catenin , Endogenous Metabolite | |
Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice. Methyl vanillate is considered to be a slightl... | |||
T1549 | Raloxifene hydrochloride | LY156758 hydrochloride,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl | Estrogen Receptor/ERR , Others , MAO , Estrogen/progestogen Receptor , Autophagy |
Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and chol... | |||
T6S0139 | Neobavaisoflavone | Apoptosis , DNA/RNA Synthesis | |
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si... | |||
T20089 | ATP | Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate | Endogenous Metabolite |
ATP (Adenosine triphosphate) provides cellular energy, participates in overall energy balance, and maintains intracellular homeostasis. ATP can act as an extracellular signaling molecule through interactions with specifi... | |||
T4S1050 | Pristimerin | Celastrol methyl ester | NF-κB , Antibacterial |
1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell... | |||
T3O2749 | L-Leucine | (S)-Leucine,Leu | mTOR |
L-Leucine ((S)-Leucine) is one of nine essential amino acids in humans (provided by food), L-Leucine is important for protein synthesis and many metabolic functions. L-Leucine contributes to regulation of blood-sugar lev... | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00680 | BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant (hFc) | Human,Mouse,Rat,Rhesus,Canine | HEK293 |
BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokin... | |||
TMPY-03235 | BST2 Protein, Human, Recombinant (His) | Human | HEK293 |
BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demons... | |||
TMPY-00663 | Alkaline Phosphatase/ALPL Protein, Human, Recombinant (His) | Human | HEK293 |
Alkaline phosphatase (ALPL) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is cal... | |||
TMPY-06842 | BMP-4 Protein, Human, Recombinant (E399D) | Human | E. coli |
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP... | |||
TMPY-03297 | BMP-2 Protein, Danio rerio (zebrafish), Recombinant | Danio rerio (zebrafish) | E. coli |
BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokin... | |||
TMPY-00681 | BMP-5 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Bone Morphogenetic Protein 5 (BMP-5) is a member of the structurally and functionally related bone morphogenetic proteins (BMPs) which constitute a novel subfamily of the transforming growth factor β (TGF-β) superfamily.... | |||
TMPY-01059 | BMPR2 Protein, Human, Recombinant (His) | Human | HEK293 |
The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signalin... | |||
TMPY-01136 | BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant | Human,Mouse,Rat,Rhesus,Canine | E. coli |
BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokin... | |||
TMPY-00614 | BMPR1A/ALK-3 Protein, Canine, Recombinant (hFc) | Canine | HEK293 |
Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta... | |||
TMPY-03037 | CD157 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPY-03038 | CD157 Protein, Rat, Recombinant (His) | Rat | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPY-00968 | CD157 Protein, Human, Recombinant (His) | Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPJ-00924 | Decorin Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Decorin, also known as PG40 and DCN, is a member of the class I family of small leucine-rich proteoglycans (SLRPs) that is expressed in the stroma of various forms of cancer and has been recently proposed to act as a gua... | |||
TMPJ-00445 | IBSP Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Bone sialoprotein 2(IBSP) is a monomeric non‑collagenous member of the SIBLING family of extracellular matrix proteins. It is principally associated with the early stages of bone mineralization. Mouse IBSP is synthesize... | |||
TMPY-00431 | BMP-4 Protein, Mouse, Recombinant (rFc) | Mouse | HEK293 |
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP... | |||
TMPY-03193 | BST2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demons... | |||
TMPY-04367 | BMPRIB Protein, Human, Recombinant (aa 149-502, His & GST) | Human | Baculovirus-Insect Cells |
BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These pro... | |||
TMPY-03362 | BMPRIB Protein, Human, Recombinant (hFc) | Human | HEK293 |
BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These pro... | |||
TMPY-00962 | BMPR1A/ALK-3 Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 |
Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta... | |||
TMPY-00594 | Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Alkaline phosphatase (ALPL) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is cal... | |||
TMPY-00446 | Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Alkaline phosphatase (ALPL) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is cal... | |||
TMPY-01374 | BMPR1A/ALK-3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta... | |||
TMPY-01764 | BMPR1A/ALK-3 Protein, Human, Recombinant (His) | Human | HEK293 |
Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta... | |||
TMPY-05485 | BMPR1A/ALK-3 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta... | |||
TMPJ-00713 | GDF-11 Protein, Human, Recombinant | Human | Human Cells |
Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. ... | |||
TMPY-04742 | BST2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demons... | |||
TMPJ-01473 | BMP-7 Protein, Human, Recombinant | Human | Human Cells |
Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist,... | |||
TMPY-01178 | CD157 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPK-00807 | Osteopontin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Secreted phosphoprotein 1 (SPP1) expression in TAMs isolated from lung adenocarcinoma tissues and PMA-treated THP-1 cells were measured. Macrophage polarization was identified by flow cytometric analysis. Cell migration ... | |||
TMPY-02674 | BST2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demons... | |||
TMPK-00538 | Osteopontin Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Ovarian cancer is one of the most lethal malignant tumors in women. Secreted phosphoprotein 1 (SPP1) plays an important role in some cancer types. The expression of SPP1 was higher in epithelial ovarian cancer tissues th... | |||
TMPK-00676 | Osteopontin Protein, Human, Recombinant (aa 17-300, His) | Human | HEK293 |
Ovarian cancer is one of the most lethal malignant tumors in women. Secreted phosphoprotein 1 (SPP1) plays an important role in some cancer types. The expression of SPP1 was higher in epithelial ovarian cancer tissues th... | |||
TMPJ-00476 | BMPG Protein, Human, Recombinant (His) | Human | Human Cells |
Bone Marrow Proteoglycan (BMPG) is a secreted protein that contains one C-type lectin domain. BMPG is the predominant constituent of the crystalline core of the eosinophil granule. BMPG is highly expressed in placenta an... | |||
TMPY-04496 | BMPRIB Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These pro... | |||
TMPY-00683 | BMPR2 Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signalin... | |||
TMPJ-00202 | CD157 Protein, Human, Recombinant (hFc) | Human | Human Cells |
The cluster of differentiation (CD) system is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family.It is generally used in immunophynotyping. CD157 was discovered in a bone marrow str... | |||
TMPJ-00325 | BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His) | Human | Human Cells |
Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A i... | |||
TMPJ-00966 | GDF-5 Protein, Human, Recombinant | Human | E. coli |
Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor... | |||
TMPY-01633 | SOST Protein, Rat, Recombinant (His) | Rat | HEK293 |
Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and prima... | |||
TMPY-00925 | SOST Protein, Human, Recombinant (His) | Human | HEK293 |
Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and prima... | |||
TMPY-04142 | RANK/TNFRSF11A Protein, Human, Recombinant (hFc) | Human | HEK293 |
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i... | |||
TMPY-03674 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc) | Human | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro... | |||
TMPY-02726 | RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro... | |||
TMPY-03364 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant | Human | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro... | |||
TMPJ-01172 | IL-17 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid seque... | |||
TMPY-00890 | Noggin/NOG Protein, Human, Recombinant (hFc) | Human | HEK293 |
Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathw... | |||
TMPY-05202 | Noggin/NOG Protein, Human, Recombinant | Human | HEK293 |
Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathw... | |||
TMPY-02594 | Noggin/NOG Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathw... | |||
TMPY-01009 | TGFBI Protein, Human, Recombinant (His) | Human | HEK293 |
TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several ... | |||
TMPJ-01470 | SCF Protein, Human, Recombinant | Human | E.coli |
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultu... | |||
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L7900 | Osteogenesis Compound Library | 320 compounds | |
A unique collection of 320 osteogenesis related compounds for high throughput and high content screening; | |||
L8400 | Hematonosis Compound Library | 524 compounds | |
A unique collection of 524 compounds related to hematologic diseases for high throughput screening (HTS) and high content screening (HCS); | |||
L9810 | Anti-Fibrosis Compound Library | 1180 compounds | |
A unique collection of 1180 potential anti-fibrosis compounds, can be used in HTS and HCS; | |||
L6230 | Miao medicine Compound Library | 540 compounds | |
A unique collection of 540 compounds featuring natural product molecules derived from Miao medicine that can be used for high-throughput and high-content screening. | |||
L8000 | Stem Cell Differentiation Compound Library | 1213 compounds | |
A unique collection of 1213 stem cell differentiation signaling targeted compounds for high throughput and high content screening; |