bis​peg4​nhs ester

Bis-PEG4-NHS ester is a bis-N-hydroxysuccinimide-activated tetraethylene glycol crosslinker. Bis-PEG4-NHS‘s NHS groups selectively condense with primary amines to form stable amide bonds, thereby covalently crosslinking proteins, peptides, or small molecules. The PEG4 moiety in Bis-PEG4-NHS ester confers good water solubility and flexibility to the conjugate, effectively suppresses nonspecific adsorption, and reduces steric hindrance, thereby supporting site-specific, copper-free click chemistry coupling between antibodies and liposomes. Bis-PEG4-NHS ester can be used for the preparation of homogeneous antibody-drug conjugates (ADCs) and the modular construction of PROTAC bifunctional molecules.