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Results for "
bim-51077
" in TargetMol Product Catalog- Inhibitors & Agonists1
- Peptide Products1
Taspoglutide
R1583, BIM51077, ITM077
T13091275371-94-3
Taspoglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist (EC50 value of 0.06 nM) used for the treatment of type 2 diabetes.
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BIM-51077C, [Aib8,35]hGLP-1(7-36)NH2
TP29061022150-16-8
Taspoglutide, acting as an agonist for the glucagon-like peptide-1 receptor (GLP-1R; Ki = 1.1 nM for the human receptor), induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM). In oral glucose tolerance tests conducted on Zucker diabetic fatty rats, Taspoglutide (administered weekly at 1 mg/animal) significantly reduced blood glucose levels and increased insulin levels. Additionally, in the same model, it also lowered blood levels of gastric inhibitory polypeptide (GIP), plasma triglycerides, and body weight.
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