autoimmunity — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9570	Enpatoran		TLR
	Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo.		TLR
T28628	RVX-297	RVX297	Epigenetic Reader Domain
	RVX-297 is a BD2 selective inhibitor of BET bromodomains. RVX-297 preferentially binds to the BD2 domains of the BET bromodomain and Extra Terminal (BET) family of protein.		Epigenetic Reader Domain
T1237	Azathioprine	BW 57-322	Apoptosis , GPR , Rho
	Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.		Apoptosis , GPR , Rho
T7657	Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat	MOG (35-55)	Others
	Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a truncated peptide derived from the human Myelin Oligodendrocyte Glycoprotein (MOG).		Others
T30077	Anisperimus	LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195	Caspase
	Anisperimus (LF 15-0195) is an immunosuppressant that enhances activation-induced T-cell death by promoting caspase-8 and caspase-10 activation at the DISC level, and prevents CNS autoimmunity by promoting the developmen...		Caspase
T11889	LTV-1		Others
	LTV-1 has the potential for autoimmunity treatment. LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM.		Others
T11559	HG-12-6		Others
	HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 (IC50: 165 nM). HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation.		Others
T37077	Syk-IN-4
	Syk-IN-4 is a potent, selective, and orally bioavailable inhibitor of SYK, demonstrating an IC50 of 0.31 nM. It targets SYK, which has been identified as a potential therapeutic target for autoimmunity and hematological ...
T63814	IDO2-IN-1
	IDO2-IN-1 is a potent, orally active indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor, exhibiting an IC50 value of 112 nM. It is applicable in research related to inflammatory autoimmunity [1].
T73335	P2X7-IN-2
	P2X7-IN-2, a P2X7 receptor inhibitor, effectively suppresses IL-Iβ release, demonstrating an inhibitory concentration (IC50) value of 0.01 nM. This compound is utilized in the study of autoimmunity, inflammation, and car...
T80573	Firastotug
	Firastotug, an IgG1κ antibody, targets CTLA4, a cytotoxic T lymphocyte-associated protein that serves as a crucial immune checkpoint in autoimmunity and cancer [1].
T77074	Lulizumab pegol
	Lulizumab pegol (BMS-931699) is an antagonist anti-CD28 antibody that effectively inhibits T-cell proliferation, making it a potential therapeutic agent for kidney transplantation and autoimmunity disease research [1].
T37287	Enpatoran hydrochloride
	Enpatoran (M5049) hydrochloride is a potent and orally active dual inhibitor of TLR7/8 with IC50 values of 11.1 nM and 24.1 nM in HEK293 cells, respectively. This compound specifically inhibits TLR7 and TLR8, while showi...
T79151	TLR8 agonist 6
	Compound A, a potent TLR8 agonist, exhibits an EC50 of 0.052 µM and promotes the production of IL-12p40 in human PBMCs with an EC50 of 0.031 µM. This compound is applicable for research in virus resistance, infection res...
T75254	P2X7-IN-2 TFA
	P2X7-IN-2 TFA (compound 58) is a P2X7 receptor inhibitor that demonstrates the capability to inhibit IL-Iβ release effectively with an IC50 value of 0.01 nM. It is utilized in research focused on autoimmunity, inflammati...
T81772	MOG (92–106), mouse, rat
	MOG (92–106), mouse, rat, is a biologically active peptide corresponding to the fragment of amino acids 92 to 106 in myelin oligodendrocyte glycoprotein (MOG) from mice and rats. It is noteworthy that mice subjected to M...