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By Target- ROCK
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Results for "
ar12286
" in TargetMol Product Catalog- Inhibitors & Agonists2
APX2009
T707331415030-15-7
APX2009 is a second-generation APE1 Ref-1 redox-specific inhibitor. APX2009 significantly reduces NFkB transcriptional activity, survivin mRNA, and survivin protein levels. APX2009 decreases prostate cancer cell proliferation and induces cell cycle arrest.
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Verosudil
AR-12286
T609241414854-42-4
Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 nM and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 mitigates steroid-induced intraocular pressure in mice by decreasing intraocular pressure through enhanced outflow of aqueous humor via the trabecular meshwork.
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